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Related Concept Videos

Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Asthma-IV: Nursing Management01:30

Asthma-IV: Nursing Management

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The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Related Experiment Video

Updated: Aug 24, 2025

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Asthma Management in Adults.

William W Busse1, Mario Castro2, Thomas B Casale3

  • 1Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wis.

The Journal of Allergy and Clinical Immunology. in Practice
|October 25, 2022
PubMed
Summary
This summary is machine-generated.

Advances in adult asthma management include understanding type 2 inflammation and using new biologics. These treatments reduce exacerbations and corticosteroid use, improving patient outcomes.

Keywords:
Airway inflammationAsthma guidelinesAsthma in adultsBiologicsT2-high and T2-low inflammation

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Area of Science:

  • Pulmonology and Allergy
  • Immunology
  • Respiratory Medicine

Background:

  • Adult asthma management has significantly evolved over the last decade.
  • Understanding of type 2 (T2) airway inflammation mechanisms has improved.
  • Epithelial cell-derived alarmins are recognized as key inflammatory mediators.

Purpose of the Study:

  • To review recent advancements in adult asthma management.
  • To highlight the role of T2 biomarkers and novel biologic therapies.
  • To discuss current and future treatment guidelines.

Main Methods:

  • Review of recent clinical studies and guideline updates on asthma management.
  • Analysis of the impact of T2 biomarkers (eosinophils, fractional exhaled nitric oxide) in treatment selection.
  • Evaluation of the efficacy and safety of newly approved biologic agents.

Main Results:

  • Five new biologics (mepolizumab, benralizumab, reslizumab, dupilumab, tezepelumab) have been approved, joining omalizumab.
  • Biologics demonstrate significant reduction in asthma exacerbations, decreasing the need for systemic corticosteroids.
  • Current guidelines support inhaled corticosteroids/long-acting beta-agonists (formoterol) for maintenance and rescue therapy.

Conclusions:

  • Novel biologic therapies have revolutionized severe asthma treatment by targeting T2 inflammation.
  • Precision medicine approaches, including phenotype/endotype-directed therapeutics, are crucial for future asthma management.
  • Continued research and guideline updates are necessary to optimize asthma control and patient care.