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Updated: Aug 24, 2025

Methods for Detecting Cough and Airway Inflammation in Mice

Methods for Detecting Cough and Airway Inflammation in Mice

Published on: August 2, 2024

Upper Airway Cough Syndrome.

Angela M Donaldson¹

¹Department of Otolaryngology Head & Neck Surgery, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL, USA.

Otolaryngologic Clinics of North America

|October 25, 2022

Summary

Upper airway cough syndrome (UACS), previously postnasal drip syndrome, is a leading cause of chronic cough. Effective treatment involves antihistamines and decongestants, with symptom resolution confirming the diagnosis.

Area of Science:

Pulmonology
Allergy and Immunology

Background:

Upper airway cough syndrome (UACS), also known as postnasal drip syndrome, is a prevalent cause of chronic cough.
UACS, asthma, and gastroesophageal reflux account for 90% of chronic cough cases.
UACS is diagnosed clinically and lacks specific diagnostic tests or objective findings.

Purpose of the Study:

To outline the diagnostic approach and treatment strategies for Upper Airway Cough Syndrome (UACS).

Main Methods:

Diagnosis of UACS is based on clinical presentation and exclusion of other causes.
Treatment involves a dual-drug regimen combining H1 receptor antihistamines and decongestants.
Confirmation of diagnosis relies on the resolution of symptoms following therapeutic intervention.

Keywords:

Chronic cough Chronic rhinosinusitis Postnasal drip Rhinitis UACS

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Main Results:

Dual therapy with H1 receptor antihistamines and decongestants is the recommended treatment for UACS.
Symptom resolution following treatment serves as confirmation of the UACS diagnosis.
UACS can occur independently or in conjunction with rhinitis and chronic rhinosinusitis.

Conclusions:

Upper airway cough syndrome is a common condition requiring specific therapeutic approaches.
The combination of antihistamines and decongestants offers an effective treatment for UACS.
Clinical diagnosis and therapeutic response are key to managing chronic cough attributed to UACS.