Opioid self-administration in rats: pharmacodynamics and pharmacokinetics

This article provides comparative data obtained during opioid self-administration in rats, using our EEG-EMG rat model of addiction. This model allows continuous recording of EEG and EMG activities and programming of intravenous drug injections. Comparative data on opioid self-administration patterns are presented. These studies on the association between EEG and behavioral correlates of opioid self-administration have contributed to the delineation of similarities and differences in pharmacodynamic and pharmacokinetic characteristics of opioids.