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Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
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In-hospital Mortality Rates in SARS-CoV-2 Patients Treated with Enoxaparin and Heparin

Moudhi Alroomi1, Ahmad Alsaber2, Bader Al-Bader3

  • 1Department of Infectious Diseases, Infectious Diseases Hospital, Shuwaikh Medical Area, Kuwait.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|October 26, 2022
PubMed

Insights

This study examined COVID-19 patient mortality based on anticoagulation use. Therapeutic anticoagulation in elderly, hypertensive patients with COVID-19 increased in-hospital mortality risk by 2.3 times.

Area of Science:

  • Medical research
  • Clinical outcomes
  • Pharmacology

Background:

  • Coronavirus disease (COVID-19) poses significant mortality risks.
  • Understanding factors influencing in-hospital mortality is crucial for patient management.
  • Anticoagulation therapies are frequently used in COVID-19 patients.

Purpose of the Study:

  • To investigate in-hospital mortality rates in COVID-19 patients.
  • To analyze the impact of enoxaparin and heparin use on mortality.
  • To identify predictors of mortality in hospitalized COVID-19 patients.

Main Methods:

  • Retrospective cohort study of 962 COVID-19 patients in Kuwait.
  • Analysis of cumulative all-cause mortality as the primary outcome.
  • Utilized multivariable logistic regression, Cox proportional hazards, and Kaplan-Meier models.

Main Results:

  • 302 patients received anticoagulation therapy, with a 20.9% mortality rate.
  • Patients on anticoagulation often had pneumonia, ARDS, and high D-dimer levels.
  • Therapeutic anticoagulation use was found to affect the risk of all-cause cumulative mortality.

Conclusions:

  • Age, hypertension, pneumonia, therapeutic anticoagulation, and methylprednisolone are strong mortality predictors.
  • Elderly, hypertensive COVID-19 patients on therapeutic anticoagulation had a 2.3 times higher mortality risk.
  • In-hospital mortality reached up to 21% in the therapeutic anticoagulation group.
Abstract

Keywords:
COVID-19SARS-CoV-2anticoagulationin-hospital mortalitypneumonia

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