Related Experiment Video

Updated: Aug 24, 2025

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles
06:58

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles

Published on: October 18, 2024

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LC3-dependent EV loading and secretion (LDELS) promotes TFRC (transferrin receptor) secretion via extracellular

Jackson O Gardner1,2, Andrew M Leidal1, Tan A Nguyen1

  • 1Department of Pathology, University of California San Francisco, San Francisco, CA, USA.

Autophagy
|October 26, 2022
PubMed
Summary

LC3-dependent EV loading and secretion (LDELS) pathway mediates transferrin receptor (TFRC) secretion via extracellular vesicles (EVs). This process requires LC3-conjugation and ESCRT machinery, but not classical autophagy proteins.

Keywords:
ATG7ATG8LC3-conjugationextracellular vesiclessecretory autophagytransferrin receptor

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