The systemic immune-inflammation index in predicting sepsis mortality.

Area of Science:

• Critical Care Medicine
• Inflammatory Markers
• Sepsis Pathophysiology

Background:

• Sepsis poses a significant threat to patient outcomes.
• Prognostic markers for sepsis are crucial for timely intervention.
• The systemic immune-inflammation index (SII) has not been previously evaluated in sepsis prognosis.

Purpose of the Study:

• To investigate the prognostic value of the systemic immune-inflammation index (SII) in patients with sepsis.
• To determine if SII can predict mortality and length of stay (LOS) in the ICU.
• To assess the incremental predictive value of SII when combined with the SOFA score.

Main Methods:

• Retrospective analysis of 267 patients with blood-culture confirmed sepsis.
• Collected clinical and laboratory data at ICU admission.
• Calculated SII, SOFA, NLR, and PLR; used regression analysis and AUROC curves to identify predictors and optimal cutoffs.

Main Results:

• The SII, NLR, and PLR were independent predictors of sepsis mortality.
• SII and SOFA score independently predicted ICU length of stay.
• SII demonstrated a significant incremental effect on the predictive ability of the SOFA score for patient outcomes.

Conclusions:

• The systemic immune-inflammation index (SII) is a valuable prognostic marker in sepsis.
• SII can be used alongside existing clinical scores to enhance patient assessment accuracy.
• This inexpensive parameter offers a practical tool for improving sepsis management.