Related Experiment Video

Updated: Aug 14, 2025

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.4K

Development of a Novel Inflammatory Index to Predict Coronary Artery Disease Severity in Patients With Acute Coronary

Sridhar Mangalesh1, Sharmila Dudani2, Nalin K Mahesh3

  • 1Department of Medicine, Army College of Medical Sciences, New Delhi, India.

Angiology
|January 11, 2023
PubMed

Insights

A new index, the systemic immune-inflammation response index (SIIRI), shows promise in predicting severe coronary artery disease (CAD). This novel marker outperformed existing indices in identifying patients with significant coronary artery disease.

Area of Science:

  • Cardiovascular Medicine
  • Inflammation Biomarkers
  • Clinical Diagnostics

Background:

  • Systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) are established predictors for coronary artery disease (CAD).
  • There is a need for improved inflammatory markers to assess CAD severity accurately.

Purpose of the Study:

  • To develop and validate a novel systemic immune-inflammation response index (SIIRI) for predicting severe CAD.
  • To compare the predictive performance of SIIRI against existing inflammatory markers.

Main Methods:

  • A novel index, SIIRI (neutrophil × monocyte × platelet ÷ lymphocyte), was calculated for 240 acute coronary syndrome patients undergoing percutaneous coronary intervention.
  • Coronary artery disease severity was assessed using the SYNTAX score.
  • Multivariate analysis and receiver operator characteristic (ROC) curves were used to evaluate SIIRI's predictive value.

Main Results:

  • SIIRI independently predicted severe CAD (OR 1.666 per 10^5 unit increase).
  • SIIRI demonstrated the highest area under the ROC curve (.771) compared to SII, SIRI, and other ratios.
  • Adding SIIRI to a baseline model significantly improved model performance, including discrimination and reclassification.

Conclusions:

  • The novel SIIRI is a valuable and independent predictor of severe coronary artery disease.
  • SIIRI offers superior predictive capability for severe CAD compared to existing inflammatory indices.
  • SIIRI enhances clinical risk stratification models for patients with acute coronary syndromes.

Keywords:
complete blood countcoronary angiographydisease severityinflammationmyocardial infarction

More Related Videos

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

487
Intravascular Ultrasound Image-Based Finite Element Modeling Approach for Quantifying In Vivo Mechanical Properties of Human Coronary Artery06:18

Intravascular Ultrasound Image-Based Finite Element Modeling Approach for Quantifying In Vivo Mechanical Properties of Human Coronary Artery

Published on: December 6, 2024

659

Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
20
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
32
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
55
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
56
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
137
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
23