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Updated: Aug 24, 2025
In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
Published on: June 15, 2018
Emerging Roles of Micrornas in Veterinary Cardiology
Ana Reis-Ferreira1,2, Joana Neto-Mendes2, Carmen Brás-Silva3
1Hospital Veterinário do Porto, Travessa Silva Porto 174, 4250-475 Porto, Portugal.
Abstract:
Over the last years, the importance of microRNAs (miRNAs) has increasingly been recognised. Each miRNA is a short sequence of non-coding RNA that influences countless genes' expression and, thereby, contributes to several physiological pathways and diseases. It has been demonstrated that miRNAs participate in the development of many cardiovascular diseases (CVDs). This review synopsises the most recent studies emphasising miRNA's influence in several CVDs affecting dogs and cats. It provides a concise outline of miRNA's biology and function, the diagnostic potential of circulating miRNAs as biomarkers, and their role in different CVDs. It also discusses known and future roles for miRNAs as potential clinical biomarkers and therapeutic targets. So, this review gives a comprehensive outline of the most relevant miRNAs related to CVDs in Veterinary Medicine.
Insights
MicroRNAs (miRNAs) are crucial in cardiovascular diseases (CVDs) for pets. This review highlights their role, diagnostic potential, and therapeutic applications in veterinary cardiology.
Area of Science:
- Veterinary Medicine
- Molecular Biology
- Cardiology
Background:
- MicroRNAs (miRNAs) are non-coding RNA sequences regulating gene expression.
- miRNAs play a significant role in physiological pathways and disease development.
- Evidence indicates miRNA involvement in the pathogenesis of cardiovascular diseases (CVDs).
Purpose of the Study:
- To review recent studies on miRNA influence in canine and feline cardiovascular diseases.
- To provide an overview of miRNA biology, function, and diagnostic potential.
- To discuss current and future roles of miRNAs as biomarkers and therapeutic targets in veterinary cardiology.
Main Methods:
- Literature review of recent scientific studies.
- Synthesis of information on miRNA function and disease association.
- Analysis of diagnostic and therapeutic applications of miRNAs in companion animals.
Main Results:
- miRNAs are implicated in the development of various cardiovascular conditions in dogs and cats.
- Circulating miRNAs show promise as non-invasive biomarkers for CVD diagnosis.
- miRNAs represent potential targets for novel therapeutic strategies in veterinary cardiology.
Conclusions:
- miRNAs are key players in the pathophysiology of cardiovascular diseases in companion animals.
- Further research into miRNAs can lead to improved diagnostics and treatments for pets with heart conditions.
- This review consolidates current knowledge on relevant miRNAs for cardiovascular health in veterinary medicine.
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