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Toward the Development of Rapid, Automated Identification Tests for Neat Organic Liquids Using Benchtop NMR
José G Napolitano1, Cassie Yang2, Breanna Conklin1
1Small Molecule Pharmaceutical Sciences, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Analytical Chemistry
|October 26, 2022
Summary
Benchtop nuclear magnetic resonance (NMR) enables material identification testing outside specialized labs. This study details automated workflows and data strategies to overcome limitations for pharmaceutical manufacturing applications.
Area of Science:
- Analytical Chemistry
- Spectroscopy
- Process Chemistry
Background:
- Benchtop nuclear magnetic resonance (NMR) offers portable spectroscopic analysis.
- Wider adoption faces challenges like low sensitivity, limited signal dispersion, and workflow automation.
Purpose of the Study:
- To develop rapid, automated identification tests for liquid raw materials in pharmaceutical manufacturing using benchtop NMR.
- To address challenges and explore opportunities for implementing benchtop NMR in routine quality control.
Main Methods:
- Cross-company collaboration focused on developing and validating benchtop NMR identification tests.
- Exploration of data collection and analysis strategies for diverse analytical scenarios.
- Testing with common organic solvents and laboratory reagents in neat form.
Main Results:
- Demonstration of potential scenarios for benchtop NMR in routine identification.
- Discussion of effective strategies for data acquisition and spectral interpretation.
- Provision of reference NMR data for common substances.
Conclusions:
- Benchtop NMR can be effectively implemented for automated material identification in pharmaceutical settings.
- Addressing instrumental and workflow challenges is key to successful adoption.
- Standardized data and methods enhance the reliability of benchtop NMR testing.
