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Updated: Aug 24, 2025

Technique for Intranasal Administration of α-Synuclein Aggregates
Published on: November 8, 2024
Surgical Management of Synucleinopathies
Sai Sriram1, Kevin Root1, Kevin Chacko1
1Department of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.
This review covers surgical treatments for synucleinopathies like Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). It explores deep brain stimulation (DBS) and focused ultrasound (FUS) for managing these neurodegenerative conditions.
Area of Science:
- Neurosurgery
- Neurology
- Molecular Medicine
Background:
- Synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), are debilitating neurodegenerative disorders.
- Current medical management offers symptomatic relief but limited disease modification for these conditions.
Purpose of the Study:
- To review and highlight current surgical management strategies for PD, DLB, and MSA.
- To explore the role of advanced neurosurgical interventions in treating synucleinopathies.
Main Methods:
- Review of literature on surgical interventions for synucleinopathies.
- Examination of deep brain stimulation (DBS) for synuclein pathophysiology.
- Analysis of focused ultrasound (FUS) applications, including blood-brain barrier (BBB) opening for therapeutic delivery.
Main Results:
- Deep brain stimulation (DBS) is a key surgical option for managing motor and non-motor symptoms in synucleinopathies.
- Focused ultrasound (FUS) shows promise for targeted drug and gene therapy delivery via temporary BBB opening.
- Recent advancements are expanding surgical options for MSA and DLB.
Conclusions:
- Neurosurgical techniques, including DBS and FUS, offer evolving treatment paradigms for synucleinopathies.
- Surgical management is becoming increasingly integral to a multidisciplinary approach for these complex diseases.
- Further research into novel surgical techniques holds potential for improved patient outcomes in synucleinopathies.
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