Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

134
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
134
Antimicrobial Proteins01:23

Antimicrobial Proteins

3.2K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
3.2K
Local Anesthetics: Chemistry and Structure-Activity Relationship01:27

Local Anesthetics: Chemistry and Structure-Activity Relationship

4.6K
Local anesthetics (LAs) are drugs that induce a temporary loss of sensation in a limited body area, preventing pain. Cocaine was the first local anesthetic discovered in the late 19th century. Cocaine is a benzoic acid ester obtained from the leaves of coca shrubs and was often used for its psychotropic effects. Cocaine was first isolated in 1860 by Albert Niemann. Sigmund Freud studied the physiological actions of cocaine. Carl Koller later introduced it into clinical practice in 1884 as a...
4.6K
Chemical Agents for Microbial Control01:27

Chemical Agents for Microbial Control

174
Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
174
Surface Membrane Barriers01:18

Surface Membrane Barriers

1.3K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.3K
Local Anesthetics: Mechanism of Action01:23

Local Anesthetics: Mechanism of Action

2.4K
Local anesthetics (LAs) block sensory and motor impulses by inhibiting the sodium channels on the nerve cell membranes. This induces temporary loss of sensation, relieving pain in a specific body area.
Local anesthetics are amphiphilic molecules consisting of a hydrophobic aromatic part linked to a hydrophilic group by an ester or amide linkage. They are weak bases and are usually available as salts, which increases their solubility and stability. Once administered, LAs exist in the body either...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Whole-Cell Biocatalysis for the Production of Structurally Diverse Methoxydihydrochalcones: Broad Activity of the <i>Yarrowia</i> Clade.

Molecules (Basel, Switzerland)·2026
Same author

Effect of Sunlight-Induced Isomerisation on the Biotransformation of 4'-Hydroxychalcones by <i>Yarrowia lipolytica</i> KCh 71.

International journal of molecular sciences·2025
Same author

Enzymatic Glycosylation of 4'-Hydroxychalcones: Expanding the Scope of Nature's Catalytic Potential.

International journal of molecular sciences·2024
Same author

Efficient Production of 4'-Hydroxydihydrochalcones Using Non-Conventional Yeast Strains.

International journal of molecular sciences·2024
Same author

Bioreduction of 4'-Hydroxychalcone in Deep Eutectic Solvents: Optimization and Efficacy with Various Yeast Strains.

International journal of molecular sciences·2024
Same author

Microbial Transformations of Halolactones and Evaluation of Their Antiproliferative Activity.

International journal of molecular sciences·2023

Related Experiment Video

Updated: Aug 24, 2025

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
07:47

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases

Published on: January 1, 2016

11.7K

Antimicrobial Activity of Lactones.

Marcelina Mazur1, Dorota Masłowiec2

  • 1Department of Food Chemistry and Biocatalysis, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland.

Antibiotics (Basel, Switzerland)
|October 27, 2022
PubMed
Summary

Novel antimicrobial lactones, including small ring ε-lactones, offer promising solutions to combat antibiotic resistance. Research explores their natural sources, synthesis, and synergistic effects with existing antibiotics.

Keywords:
antibacterial activityantimicrobial compoundsisolation of lactoneslactonesquorum sensing

More Related Videos

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
11:56

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

12.6K
Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of M. abscessus Treatments
07:50

Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of M. abscessus Treatments

Published on: October 25, 2024

1.8K

Related Experiment Videos

Last Updated: Aug 24, 2025

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
07:47

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases

Published on: January 1, 2016

11.7K
Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
11:56

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

12.6K
Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of M. abscessus Treatments
07:50

Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of M. abscessus Treatments

Published on: October 25, 2024

1.8K

Area of Science:

  • Medicinal Chemistry
  • Microbiology
  • Natural Product Chemistry

Background:

  • Antibiotic resistance is a major global health threat, necessitating new therapeutic strategies.
  • Lactones, known for historical medicinal use, are emerging as a promising class of antimicrobial compounds.
  • The urgent need for novel antimicrobial agents drives research into diverse chemical structures.

Purpose of the Study:

  • To review recent advancements in antimicrobial lactones, focusing on smaller ring sizes (up to seven-membered ε-lactones).
  • To highlight the isolation, synthesis, and antimicrobial potential of these lactone compounds.
  • To explore their synergistic activities with antibiotics and impact on bacterial quorum sensing.

Main Methods:

  • Literature review of recent studies on antimicrobial lactones.
  • Analysis of isolation and chemical synthesis methods for ε-lactones.
  • Examination of data on synergistic antimicrobial activity and quorum sensing inhibition.

Main Results:

  • Recent literature continuously describes novel lactone compounds with significant antimicrobial potential.
  • Smaller ring lactones, particularly ε-lactones, show promise as novel antimicrobial agents.
  • These compounds exhibit synergistic effects with antibiotics and influence bacterial quorum sensing.

Conclusions:

  • Antimicrobial lactones, especially smaller ring variants, represent a vital area for developing new treatments against resistant bacteria.
  • Further research into lactone structures, synthesis, and mechanisms of action is crucial for drug development.
  • Lactones offer a promising avenue to overcome the challenges posed by antibiotic resistance.