Related Experiment Video
Updated: Aug 23, 2025
05:31
Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
Published on: May 16, 2025
260
Emerging Role of Non-Coding RNAs in Aortic Dissection
Wei Ding1, Ying Liu2,3, Zhe Su1
1The Affiliated Hospital of Qingdao University, Qingdao Medical College, Qingdao University, Qingdao 266021, China.
Biomolecules
|October 27, 2022
Summary
Non-coding RNAs (ncRNAs) are crucial in aortic dissection (AD) development. This review details how ncRNAs regulate AD and their potential as biomarkers and therapeutic targets for patient treatment.
Area of Science:
- Cardiovascular Biology
- Molecular Biology
- Genetics
Background:
- Aortic dissection (AD) is a life-threatening cardiovascular condition with high mortality.
- The precise mechanisms underlying AD pathogenesis, including inflammation and cell apoptosis, remain incompletely understood.
- Non-coding RNAs (ncRNAs) are increasingly recognized for their roles in disease progression.
Purpose of the Study:
- To review the current understanding of ncRNA involvement in aortic dissection.
- To explore the regulatory mechanisms of ncRNAs in AD pathogenesis.
- To highlight the clinical potential of ncRNAs as biomarkers and therapeutic targets for AD.
Main Methods:
- Systematic review of recent scientific literature.
- Analysis of studies investigating ncRNA function in cardiovascular diseases, specifically AD.
- Synthesis of findings on ncRNA regulation and clinical applications.
Main Results:
- Dysregulation of ncRNAs, including microRNAs, lncRNAs, and circRNAs, contributes to AD development.
- ncRNAs modulate AD by affecting target gene expression and protein activity.
- Specific ncRNAs show promise as diagnostic biomarkers and therapeutic targets for AD.
Conclusions:
- ncRNAs play significant roles in the pathogenesis of aortic dissection.
- Understanding ncRNA mechanisms offers new avenues for AD diagnosis and treatment.
- ncRNA-based strategies hold potential for improving outcomes in AD patients.
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