Related Experiment Video
Updated: Aug 23, 2025
14:57
Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
Published on: March 23, 2011
94.3K
Relationships between Inflammation and Age-Related Neurocognitive Changes
Run Jin1,2, Aidan Kai Yeung Chan1,3, Jingsong Wu4
1State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong 999077, China.
International Journal of Molecular Sciences
|October 27, 2022
Summary
Inflammation significantly impacts age-related cognitive decline, linked to immune system aging. This review explores mechanisms and proposes therapies to mitigate cognitive changes associated with inflammation.
Area of Science:
- Neuroscience
- Immunology
- Gerontology
Background:
- Age-related immune dysfunction involves immune cell senescence and elevated inflammatory markers.
- Chronic inflammation is linked to age-related neurocognitive changes and neuroinflammation.
- Immune system aging and cognitive function are interconnected, influencing brain health in later life.
Purpose of the Study:
- To review the mechanisms linking inflammation and age-related neurocognitive changes.
- To explore the role of key molecules in the immune-cognition interplay.
- To propose therapeutic strategies for mitigating inflammation-associated cognitive decline.
Main Methods:
- Literature review of studies on inflammation, immune senescence, and neurocognition.
- Analysis of mechanisms including vascular inflammation, neuroinflammation, and metabolic dysfunctions.
- Identification of key molecules involved in immune-cognition interactions.
Main Results:
- Age-related immune dysfunctions contribute to neuroinflammation and cognitive impairment.
- Vascular inflammation, organelle dysfunction, cholesterol metabolism, and glymphatic system impairment are key mechanisms.
- Specific molecules play crucial roles in the immune-cognition interplay.
Conclusions:
- Understanding the multifaceted role of chronic inflammation is vital for neurocognitive disorders.
- Pharmacological and behavioral interventions show promise for managing inflammation-related cognitive decline.
- Further research can guide preventative strategies to delay or buffer age-related cognitive decline.
More Related Videos
Related Concept Videos
01:26Aging
151
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
151
01:19The Effect of Aging on Tissues
2.2K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.2K
01:19Psychoneuroimmunology: Diabetes and Cancer
56
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
56
01:30Cognitive Development During Adulthood
212
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
212
01:26Alzheimer's Disease: Overview
626
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
626
01:23Role of Neurotransmitters in Memory
759
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
759