Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Methods of reducing fever

Methods of reducing fever

The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Multifaceted Role of Pyroptosis: Molecular Mechanisms, Crosstalk with Other Cell Death Pathways, and Therapeutic Implications.

MedComm·2026

Same author

Placental Pathophysiology in Maternal Psychoactive Substance Use: Biological, Clinical, and Forensic Perspectives.

Cells·2026

Same author

Beyond Molecular Classification in Metastatic Triple-Negative Breast Cancer: Toward Subtype-Guided Precision Oncology.

International journal of molecular sciences·2026

Same author

Sex-Specific Responses to Intermittent Fasting: A Narrative Review Across Physiological, Clinical, and Psychosocial Contexts.

Nutrients·2026

Same author

Determination of protein markers of inflammasome formation and ferroptosis in thyroid cancer based on gender.

Journal of Cancer·2026

Same author

Design of a Predictive Recurrence Scoring System in Oral Squamous Cell Carcinoma.

Journal of clinical medicine·2026

Search research articles

Related Experiment Video

Updated: Jun 25, 2026

Thermal Ablation for the Treatment of Abdominal Tumors

Thermal Ablation for the Treatment of Abdominal Tumors

Published on: March 7, 2011

Hyperthermic Intraperitoneal Chemotherapy and Recirculation with CO₂: A Safe Technique.

Remedios Gómez-Sanz^1,2, Enrique Ovejero-Merino^1,2, Inmaculada Lasa-Unzúe¹

¹Department of General and Digestive Surgery, Príncipe de Asturias Teaching Hospital, 28805 Madrid, Spain.

Journal of Clinical Medicine

|October 27, 2022

Summary

This study found that closed Hyperthermic IntraPEritoneal Chemotherapy (HIPEC) with CO2 agitation offers comparable safety and survival rates to traditional methods for peritoneal carcinomatosis. The technique demonstrated low mortality and reduced morbidity, making it a viable option post-cytoreductive surgery.

Keywords:

Spanish PRS Group cytoreductive surgery intraoperative intraperitoneal chemotherapy intraperitoneal chemotherapy peritoneal carcinomatosis

More Related Videos

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

Published on: November 21, 2017

Related Experiment Videos

Last Updated: Jun 25, 2026

Thermal Ablation for the Treatment of Abdominal Tumors

Thermal Ablation for the Treatment of Abdominal Tumors

Published on: March 7, 2011

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

Published on: November 21, 2017

Area of Science:

Oncology
Surgical Oncology
Gastroenterology

Background:

Hyperthermic IntraPEritoneal Chemotherapy (HIPEC) is a key treatment for peritoneal carcinomatosis following cytoreductive surgery.
HIPEC has shown improved survival outcomes compared to traditional therapies.
Evaluating novel HIPEC delivery systems is crucial for optimizing patient outcomes.

Purpose of the Study:

To assess the safety, efficacy, and survival rates of a closed HIPEC technique using the CO2-agitation system Combat PRS®.
To compare these outcomes against traditional open and closed HIPEC methods.

Main Methods:

A retrospective study involving 482 patients across 11 Spanish hospitals.
HIPEC was administered using the closed Combat PRS® system with CO2 recirculation.
Outcomes analyzed included overall survival (OS), disease-free survival (DFS), morbidity, and mortality.

Main Results:

Mortality rate was 1.66%, comparable to other HIPEC techniques.
Morbidity rate of Clavien-Dindo (CD) III/IV complications was 9.96%, lower than reported for other series.
Survival rates were 86% 1-year OS, 54% 3-year OS, 77% 1-year DFS, and 31% 3-year DFS.

Conclusions:

The closed HIPEC technique with CO2 agitation (Combat PRS®) is as safe as standard open and closed procedures.
This method achieves similar, very low mortality (1.66%) and reduced morbidity (9.96% CD III/IV complications).
It offers comparable survival outcomes, representing a safe and effective option for HIPEC delivery.