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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
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Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
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Nano-Clays for Cancer Therapy: State-of-the Art and Future Perspectives.

Francesca Persano1, Stefano Leporatti2

  • 1Department of Mathematics and Physics, University of Salento, 73100 Lecce, Italy.

Journal of Personalized Medicine
|October 27, 2022
PubMed
Summary

Natural nano-clays show great potential as biocompatible nanocarriers for targeted cancer therapy. These materials offer improved drug delivery, stabilization, and controlled release of anticancer agents, addressing limitations of conventional treatments.

Keywords:
cancer therapydelivery systemshalloysitekaolinitemontmorillonitenano-claysnanocarriers

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Oncology

Background:

  • Cancer remains a leading cause of death, with current therapies often limited by efficacy and severe side effects.
  • Conventional chemotherapeutics exhibit non-specific toxicity, necessitating novel therapeutic strategies.
  • Natural nanomaterials offer a promising alternative for improved cancer treatment.

Purpose of the Study:

  • To review the potential of nano-clays as advanced drug delivery systems for cancer therapy.
  • To highlight the unique properties of nano-clays that make them suitable for oncology applications.
  • To discuss the role of nano-clays in enhancing the efficacy and reducing the toxicity of anticancer agents.

Main Methods:

  • Review of scientific literature on nano-clays in cancer therapy.
  • Analysis of the physico-chemical and morphological characteristics of various nano-clays.
  • Examination of nano-clay applications as nanocarriers for anticancer drugs.

Main Results:

  • Nano-clays possess desirable properties like biocompatibility, high surface area, and controlled release capabilities.
  • Specific nano-clays (halloysite, montmorillonite, kaolinite) improve drug dissolution and modulate release kinetics.
  • Nano-clays can serve as effective nanocarriers, improving stabilization and transport of therapeutic agents.

Conclusions:

  • Nano-clays represent a promising class of natural nanomaterials for innovative cancer treatment strategies.
  • Their unique crystalline structure and tunable properties position them as valuable tools in nanomedicine for oncology.
  • Further research into nano-clay applications can lead to more effective and safer cancer therapies.