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Related Experiment Video

Updated: Aug 23, 2025

Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications

Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications

Published on: February 23, 2017

Improved Enamel Acid Resistance Using Biocompatible Nano-Hydroxyapatite Coating Method.

Ryouichi Satou¹, Miyu Iwasaki¹, Hideyuki Kamijo²

¹Department of Epidemiology and Public Health, Tokyo Dental College, Tokyo 101-0061, Japan.

Materials (Basel, Switzerland)

|October 27, 2022

Summary

A novel dental caries prevention method using bioapatite (BioHap) nanoparticles significantly enhances enamel acid resistance. This biocompatible coating offers superior protection against demineralization compared to conventional fluoride treatments.

Keywords:

apatite demineralization enamel fluoride preventive dentistry

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Area of Science:

Biomaterials Science
Dental Research
Nanotechnology

Background:

Dental caries remains a significant global health issue.
Current prevention methods, like topical fluoride, have limitations.
Novel biomaterials offer potential for enhanced caries prevention.

Purpose of the Study:

To develop and evaluate a new dental caries prevention method using bioapatite (BioHap).
To compare the efficacy of BioHap with high-concentration fluoride against conventional fluoride application.
To assess the impact on enamel acid resistance and demineralization.

Main Methods:

Utilized eggshell-derived nano-bioapatite (BioHap) for tooth surface application.
Applied a high-concentration fluoride method combined with BioHap.
Compared against conventional topical fluoride application on bovine enamel.
Evaluated enamel acid resistance using qualitative and quantitative analyses.

Main Results:

The BioHap group showed reduced enamel loss and improved micro-Vickers hardness.
Qualitative and quantitative analyses revealed a thick coating layer and decreased demineralization.
BioHap with high-concentration fluoride demonstrated superior demineralization suppression compared to conventional methods.
Observed decreased reaction area depth, mineral loss value, and lesion depth.

Conclusions:

The proposed biocompatible nano-hydroxyapatite coating method effectively prevents dental caries.
BioHap offers enhanced enamel protection and demineralization suppression.
This method is a promising new standard for professional dental care and caries prevention.