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Related Concept Videos

Shearing Stress01:19

Shearing Stress

819
Shearing stress, denoted by the Greek letter tau (τ), is stress caused by forces acting transversely on an object. These forces create internal ones within the entity in the plane where the external forces are applied. The resultant of these internal forces is the shear in the section.
The average shearing stress can be calculated by dividing the shear by the area of the cross-section.
819
Stresses under Combined Loadings01:23

Stresses under Combined Loadings

222
When analyzing a bent tube with a circular cross-section subjected to multiple forces, it is crucial to determine the stress distribution in order to maintain structural integrity under varied load conditions.
The process begins by slicing the tube at critical points and analyzing the internal forces and stress components at these sections, focusing on the centroid. Normal stresses, generated by axial forces and bending moments, are either compressive or tensile and vary across the section from...
222
Unsymmetric Loading of Thin-Walled Members01:23

Unsymmetric Loading of Thin-Walled Members

139
Thin-walled members with non-symmetrical cross-sections are vital to engineering structures, offering material efficiency and structural integrity. However, unsymmetrical loading on these members leads to complex stress distributions, resulting in simultaneous bending and twisting can cause deformation or structural failure. The interaction between bending and twisting requires detailed analysis to ensure structural resilience.
The concept of the shear center is crucial in countering the...
139
Stress: General Loading Conditions01:15

Stress: General Loading Conditions

365
To grasp the intricacy of real-world conditions where multiple loads are applied simultaneously to a structure, one might visualize a section passing through a specific point within a body, aligned parallel to the xy plane. This section is subjected to various forces, including original loads, normal forces, and shearing forces.
The shearing force, possessing potential directionality within the plane of the section, is simplified into two component forces running parallel to the x and y axes....
365
Shearing Stresses in a Beam: Problem Solving01:14

Shearing Stresses in a Beam: Problem Solving

284
A cantilever beam with a rectangular cross-section under distributed and point loads experiences shearing stresses. The analysis begins by identifying the loads acting on the beam. Then, the reactions at the beam's fixed end are calculated using equilibrium equations. The vertical reaction is a combination of the distributed and point loads, while the moment reaction is the sum of their moments. The shear force distribution along the beam, resulting from these loads, is established by...
284

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Wall Shear Stress Analysis and Optimization in Tissue Engineering TPMS Scaffolds.

Tiago H V Pires1, John W C Dunlop2, André P G Castro1,3

  • 1IDMEC, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal.

Materials (Basel, Switzerland)
|October 27, 2022
PubMed
Summary
This summary is machine-generated.

Scaffold design for bone tissue engineering impacts cell growth. Smooth scaffolds with tetrahedral elements showed 35% higher wall shear stress (WSS) than non-smooth ones with hexahedral elements, demonstrating CFD

Keywords:
bone tissue engineeringcomputational fluid dynamicsoptimizationsimulated annealingtriply periodic minimum surfaceswall shear stress

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Area of Science:

  • Biomaterials Science
  • Biomedical Engineering
  • Computational Fluid Dynamics

Background:

  • Scaffold design is critical for bone tissue engineering (BTE).
  • Fluid flow within scaffolds generates wall shear stress (WSS), influencing cellular processes.
  • Optimizing WSS is key for effective new tissue formation.

Purpose of the Study:

  • To analyze average WSS in Schwartz diamond (SD) and gyroid (SG) scaffolds with varying surface topologies and mesh elements.
  • To investigate the use of simulated annealing optimization for designing BTE scaffolds with targeted WSS.
  • To evaluate the combined efficacy of CFD and optimization in BTE scaffold design.

Main Methods:

  • Computational fluid dynamics (CFD) analysis of SD and SG scaffolds.
  • Comparison of WSS in scaffolds with smooth/non-smooth surfaces and tetrahedral/hexahedral elements.
  • Implementation of the simulated annealing algorithm for scaffold WSS optimization.

Main Results:

  • Scaffolds with smooth surfaces and tetrahedral elements exhibited 35% higher WSS than those with non-smooth surfaces and hexahedral elements.
  • The simulated annealing algorithm successfully achieved WSS levels near 5 mPa (physiological range).
  • The optimization process reached target WSS within 100 iterations.

Conclusions:

  • Scaffold surface topology and mesh element type significantly affect WSS.
  • CFD analysis is effective for evaluating WSS in BTE scaffolds.
  • Combining CFD with optimization algorithms like simulated annealing enables precise WSS control for improved BTE scaffold design.