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Enhancing the Photo and Thermal Stability of Nicotine through Crystal Engineering with Gentisic Acid
Devin J Angevine1, Kristine Joy Camacho2, Javid Rzayev3
1Department of Chemistry, University at Buffalo 730 Natural Sciences Complex, Buffalo, NY 14260-3000, USA.
Abstract:
The use of crystal engineering to convert liquids into crystalline solids remains a powerful method for inhibiting undesired degradation pathways. When nicotine, a liquid sensitive to both light and air, is combined with the GRAS-listed compound, gentisic acid, the resulting crystalline solid, exhibits enhanced photo and thermal stability. Despite a modest ΔTm of 42.7 °C, the melting point of 155.9 °C for the nicotinium gentisate salt is the highest reported for nicotine-containing crystalline solids. An analysis of the crystal packing and thermodynamic properties provides context for the observed properties.
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