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Biofunctionalization of Magnetic Nanomaterials
Published on: July 16, 2020
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Smart and Multi-Functional Magnetic Nanoparticles for Cancer Treatment Applications: Clinical Challenges and Future
Elham Aram1,2, Masome Moeni3, Roya Abedizadeh1
1Department of Cancer Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Babol 47138-18981, Iran.
Nanomaterials (Basel, Switzerland)
|October 27, 2022
Summary
Smart magnetic nanoparticles (SMNPs) offer advanced cancer theranostics by combining imaging and therapy. This review highlights their potential, fabrication, and clinical challenges for targeted drug delivery and controlled release.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Iron oxide nanoparticles (IONPs) possess unique magnetic and biocompatible properties.
- IONPs are explored for magnetic hyperthermia (MHT), MRI, and ultrasound (US) imaging.
- Their drug-loading capacity facilitates targeted drug delivery (TDD) for cancer treatment.
Purpose of the Study:
- To provide an overview of magnetic nanoparticles (MNPs) for cancer theranostics.
- To discuss fabrication, surface coatings, and targeting strategies for smart magnetic nanoparticles (SMNPs).
- To review advancements and clinical challenges of SMNPs in cancer theranostics.
Main Methods:
- Literature review of MNPs and SMNPs in cancer theranostics.
- Analysis of fabrication procedures and surface functionalization.
- Examination of targeting approaches and multimodal applications.
Main Results:
- SMNPs enable controlled drug release (CDR) and TDD via external/internal stimuli.
- SMNPs can be integrated with MRI, MHT, and US for multimodal theranostics.
- Significant progress has been made in SMNP development for cancer therapy.
Conclusions:
- SMNPs present numerous advantages over traditional chemotherapy.
- Clinical translation of SMNPs faces challenges that require further research.
- Future research should focus on overcoming clinical predicaments for SMNP applications.
