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Related Concept Videos

Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
297
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

303
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
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Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
412
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

225
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
225
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

186
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
186
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Updated: Aug 23, 2025

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
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Tuberculosis in an Aging World.

Angélica M Olmo-Fontánez1,2, Joanne Turner1

  • 1Host Pathogen Interactions and Population Health Programs, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.

Pathogens (Basel, Switzerland)
|October 27, 2022
PubMed
Summary
This summary is machine-generated.

Elderly individuals are more susceptible to tuberculosis (TB) due to age-related lung function decline and comorbidities. Understanding these factors is crucial for developing new therapeutic strategies against TB in older populations.

Keywords:
M. tbagingcomorbiditieselderlyinflammagingtuberculosis

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Area of Science:

  • Gerontology
  • Infectious Diseases
  • Pulmonology

Background:

  • Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), is a leading infectious cause of death globally.
  • Over one-fourth of the world's population harbors latent M.tb infection.
  • The elderly (aged 65+) represent a significant reservoir for M.tb and face increased susceptibility and mortality risks.

Purpose of the Study:

  • To review the reasons for increased TB susceptibility and mortality in the elderly.
  • To focus on the impact of pulmonary function and comorbidities on TB risk in older adults.
  • To inform the development of novel therapeutic strategies for maintaining lung health and combating respiratory infections in aging populations.

Main Methods:

  • This review synthesizes existing literature on aging, lung function, comorbidities, and tuberculosis.
  • It focuses on the molecular and cellular mechanisms underlying natural lung aging.
  • The review examines challenges faced by the elderly, including decreased lung function, immuno-senescence, inflammaging, and adverse drug effects.

Main Results:

  • Aging is associated with decreased lung function and immune system changes (immuno-senescence, inflammaging), increasing vulnerability to respiratory infections.
  • Older adults often have comorbidities that complicate TB diagnosis and treatment.
  • Reduced tolerance to anti-TB drugs and lack of age-specific diagnostic tools further exacerbate the problem.

Conclusions:

  • The elderly are disproportionately affected by TB due to a combination of physiological aging processes and increased comorbidity burden.
  • Targeting age-related changes in lung function and immunity is essential for effective TB prevention and treatment in this demographic.
  • Further research into age-specific diagnostics and therapeutics is critical to reduce TB mortality in older adults.