Strategies for Improving Peptide Stability and Delivery

Area of Science:

• Biochemistry and Pharmaceutical Sciences
• Drug Delivery Systems
• Molecular Biology

Background:

• Peptides are crucial in immunology, diagnostics, and drug discovery due to specificity and safety.
• Poor metabolic stability and short half-life limit peptide applications as active pharmaceutical ingredients or imaging agents.

Purpose of the Study:

• To review technologies enhancing peptide stability and therapeutic impact.
• To highlight strategies overcoming limitations in peptide drug delivery.

Main Methods:

• Review of structural modifications for enzymatic degradation resistance.
• Analysis of novel delivery tactics for improved peptide targeting.
• Examination of cell-penetrating peptides and stapled peptides.

Main Results:

• Selected technologies significantly enhance peptide resistance to enzymatic degradation.
• Novel delivery tactics improve the ability of peptides to reach targets functionally.
• Stapled modified peptides show superior stability compared to parent peptides.

Conclusions:

• Overcoming peptide instability is key to maximizing therapeutic and diagnostic potential.
• Advanced delivery strategies, including modified peptides, offer promising solutions for peptide-based applications.