Recent Progress on Hyaluronan-Based Products for Wound Healing Applications

Area of Science:

• Biomaterials Science
• Nanotechnology
• Regenerative Medicine

Background:

• Hyaluronic acid (HA) is a biocompatible, biodegradable polymer with inherent hemostatic and antibacterial properties.
• HA-based nanocomposites are recognized for their potential to improve wound healing outcomes.
• The wound healing process involves four sequential phases: hemostasis, inflammation, proliferation, and maturation.

Purpose of the Study:

• To review the application of HA-based nanocomposites in wound healing.
• To elucidate the role of HA in each phase of wound healing.
• To discuss the incorporation of metal nanoparticles (MNPs) or metal oxide nanoparticles (MO-NPs) and antibiotics within HA nanocomposites for enhanced therapeutic effects.

Main Methods:

• Review of existing literature on HA-based nanocomposites for wound healing.
• Analysis of the mechanisms by which HA and its nanocomposites influence wound healing phases.
• Examination of studies involving MNPs/MO-NPs and antibiotic-loaded HA nanocomposites.

Main Results:

• HA-based nanocomposites effectively support all four phases of wound healing: hemostasis, inflammation, proliferation, and maturation.
• The integration of MNPs/MO-NPs and antibiotics into HA nanocomposites enhances antibacterial activity and accelerates healing.
• HA derivatives and other polymers in composite formulations further contribute to improved wound healing efficacy.

Conclusions:

• HA-based nanocomposites represent a promising strategy for advanced wound healing applications.
• The multifaceted properties of HA, combined with nanoparticles and antibiotics, offer significant therapeutic advantages.
• Further research and clinical trials in animal models validate the potential of these nanocomposites for wound management.