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Related Experiment Video

Updated: Aug 23, 2025

Vaccinia Reporter Viruses for Quantifying Viral Function at All Stages of Gene Expression

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Monkeypox: A Comprehensive Review.

Harapan Harapan^1,2,3,4, Youdiil Ophinni^5,6, Dewi Megawati^7,8

¹Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia.

|October 27, 2022

Summary

This summary is machine-generated.

The 2022 monkeypox outbreak spread globally, highlighting human-to-human transmission. This review offers comprehensive information on monkeypox epidemiology, clinical features, and management for public health efforts.

Keywords:

emergency emerging viral infectious diseases epidemic international concern prevention public health vaccination zoonosis

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Area of Science:

Public Health
Infectious Diseases
Virology

Background:

The 2022 multi-country monkeypox outbreak emerged amidst the COVID-19 pandemic, spreading rapidly across 104 countries.
Monkeypox virus (MPXV), known since 1959, has shown increased human-to-human transmissibility and community spread in non-endemic regions.
The re-emergence of monkeypox as a public health emergency of international concern necessitates updated information for global health stakeholders.

Purpose of the Study:

To provide a comprehensive overview of the re-emerging monkeypox viral disease.
To inform healthcare workers, policymakers, and the public about monkeypox epidemiology, etiology, pathogenesis, clinical features, diagnosis, and management.
To discuss current preventive measures, control strategies, vaccine developments, and future research directions.

Main Methods:

This review synthesizes current knowledge on monkeypox through a comprehensive literature search.
Key aspects covered include epidemiology, viral characteristics, disease progression, diagnostic approaches, and therapeutic interventions.
The review also examines public health responses, including vaccination and control strategies.

Main Results:

The 2022 outbreak demonstrated unprecedented global spread and human-to-human transmission, particularly in non-endemic areas.
MPXV exhibits distinct epidemiological patterns and clinical manifestations requiring prompt diagnosis and management.
Vaccine development and public health interventions are crucial for mitigating the impact of the re-emerging disease.

Conclusions:

A thorough understanding of monkeypox epidemiology, clinical presentation, and transmission dynamics is essential for effective public health response.
Timely diagnosis, appropriate management, and strategic implementation of preventive measures, including vaccination, are critical.
Continued research is necessary to address knowledge gaps and combat the global threat of monkeypox.