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FLASH radiotherapy: an emerging approach in radiation therapy
Natalia Matuszak1,2, Wiktoria Maria Suchorska1,2, Piotr Milecki1,3
1Electroradiology Department, Poznan University of Medical Sciences, Poznan, Poland.
Summary
FLASH radiotherapy (FLASH-RT) uses ultra-high dose rates to reduce toxicity in healthy tissues without harming cancer treatment. Further technological development is needed for widespread clinical use.
Area of Science:
- Radiation Oncology
- Medical Physics
Background:
- FLASH radiotherapy (RT) delivers radiation at ultra-high dose rates.
- This technique shows potential for reducing toxicity in healthy tissues while maintaining anti-cancer efficacy compared to conventional RT.
Purpose of the Study:
- To review existing data on FLASH-RT.
- To discuss the current understanding, technological challenges, and underlying physics of FLASH-RT.
Main Methods:
- Review of published preclinical and clinical data on FLASH-RT.
- Analysis of the technological requirements and physical principles of ultra-high dose rate radiation delivery.
Main Results:
- FLASH-RT demonstrates reduced toxicity in preclinical models.
- Current clinical applications are limited, with most experience using FLASH electrons.
- Development of FLASH photon beam capabilities is crucial for clinical integration.
Conclusions:
- FLASH-RT is a promising radiotherapy modality with a favorable therapeutic ratio.
- Technological advancements, particularly for photon beams, are necessary for broader clinical adoption.
