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Updated: Aug 23, 2025
A Real-World High-Intensity Interval Training Protocol for Cardiorespiratory Fitness Improvement
Published on: February 22, 2022
High-intensity aerobic interval training and resistance training are feasible in rectal cancer patients undergoing
Elise Piraux1, Gregory Reychler2, David Vancraeynest3
1Pôle de Neuro Musculo Skeletal Lab, Pôle de Pneumologie, ORL and Dermatologie, Institut de Recherche Expérimentale et Clinique, Clinical Neuroscience, Institute of Neurosciences, Université Catholique de Louvain, Haute Ecole Léonard de Vinci, PARNASSE-ISEI, Secteur de Kinésithérapie, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
Background:
There has been growing evidence of the benefits of high-intensity aerobic interval training (HIIT) and resistance training (RES) for populations with cancer. However, these two modalities have not yet been performed alone in rectal cancer patients undergoing neoadjuvant chemoradiotherapy (NACR T). Therefore, this study aimed to determine the feasibility of HIIT and RES in rectal cancer patients undergoing NACR T.
Materials And Methods:
Rectal cancer patients set to undergo NACRT were randomly assigned to HIIT intervention, RES intervention, or the usual care. Feasibility of HIIT and RES was assessed by measuring recruitment rate, adherence (retention rate, attendance rate, and exercise sessions duration and intensity), and adverse events. Endpoints (changes in fatigue, health-related quality of life, depression, daytime sleepiness, insomnia, sleep quality, functional exercise capacity, and executive function) were assessed at baseline and at week 5.
Results:
Among the 20 eligible patients, 18 subjects were enrolled and completed the study, yielding a 90% recruitment rate and 100% retention rate. Attendance at exercise sessions was excellent, with 92% in HIIT and 88% in RES. No exercise-related adverse events occurred.
Conclusion:
This study demonstrated that HIIT and RES are feasible in rectal cancer patients undergoing NACR T.
Trial Registration:
www.clinicaltrials.gov, NCT03252821 (date of registration: March 30, 2017).
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