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Updated: Aug 23, 2025
Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli
Published on: March 24, 2023
Escherichia coli resistance patterns, empiric and targeted antibiotic prescriptions in children: a single center
Danilo Buonsenso1, Davide Pata2, Barbara Fiori3
1. danilobuonsenso@gmail.com.
Insights
Antibiotic resistance in pediatric E. coli infections is a growing concern. This study found low resistance rates to common antibiotics, but invasive devices and intensive care were linked to higher resistance to cephalosporins and aminoglycosides.
Area of Science:
- Pediatric Infectious Diseases
- Antimicrobial Resistance Epidemiology
Background:
- Antibiotic resistance poses a significant public health threat.
- Limited epidemiological data exists on E. coli resistance in pediatric populations.
Purpose of the Study:
- To analyze E. coli antibiotic resistance patterns in children.
- To identify factors associated with antibiotic resistance in pediatric E. coli infections.
Main Methods:
- Retrospective analysis of pediatric patients (<18 years) with E. coli.
- Data collected from April 2016 to April 2018.
- Included 205 pediatric subjects (mean age 1.6 years).
Main Results:
- Low E. coli resistance rates observed for Amoxicillin/Clavulanate (20%), Cephalosporins (6.3%), and Aminoglycosides (6.3%).
- No resistance detected to Carbapenems.
- Invasive devices and intensive care admissions correlated with Cephalosporin and Aminoglycoside resistance (P < 0.001; OR 9.21 and P < 0.004; OR 5.42, respectively).
Conclusions:
- Aminoglycosides and Cephalosporins are frequently used empiric therapies.
- Targeted antibiotic therapies are not consistently implemented post-antibiogram.
- Findings can inform antimicrobial stewardship and optimize antibiotic use in pediatric care.
Background And Aim:
Antibiotic resistance represents one of the major public health issues, due to the potential future ineffectiveness of available antibiotics. However, epidemiological studies on E. coli antibiotic resistance patterns in the pediatric population are limited.
Methods:
We conducted a retrospective analysis on children younger than 18 years of age admitted to the Department of Pediatrics from April 2016 to April 2018 with E. coli isolation on biological materials.
Results:
205 subjects were included in the study (mean age 1.6 years). We found an overall low rate of resistance of E. coli isolates to Amoxicil-lin/Clavulanate (20%), Cephalosporins (6.3%) and Aminoglycosides (6.3%), while no isolates were resistant to Carbapenems. Presence of invasive devices and intensive care admissions were as-sociated with resistance to Cephalosporines (P < 0.001; OR 9.21, 95% CI 2.7 - 31.39) and Amino-glycosides (P < 0.004; OR 5.42, 95% CI 1.71 - 17.15), while no factors associated with resistance to the other antibiotics were found.
Conclusions:
Aminoglycosides and Cephalosporins were frequently used as empiric therapy, whereas targeted therapies aimed at sparing these classes of antibiotics once antibiograms were available have not always been established. These data may inform local antimicrobial stewardship and guide the development of programs aiming at a better use of antibiotics.
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