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Related Experiment Video

Updated: Aug 23, 2025

Assessing Urinary Tract Junction Obstruction Defects by Methylene Blue Dye Injection
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[A man with cola-coloured urine].

Mees Dorleijn1,2, Yvo Smulders1

  • 1FundashonMariadal, afd. Interne Geneeskunde, Kralendijk, Caribisch Nederland.

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|October 27, 2022
PubMed
Summary

Heavy exercise can cause rhabdomyolysis, a condition where muscle breakdown releases damaging proteins into the blood. Prompt hydration rapidly lowered creatine kinase levels, preserving normal kidney function in this case.

Area of Science:

  • Sports Medicine
  • Nephrology
  • Clinical Biochemistry

Background:

  • Rhabdomyolysis is a clinical syndrome characterized by muscle damage and the release of intracellular contents into the circulation.
  • Intense physical exertion is a known, albeit less common, cause of rhabdomyolysis.
  • Early recognition and intervention are crucial for preventing renal complications.

Observation:

  • A 37-year-old male presented with abnormal urine color following strenuous exercise.
  • Initial laboratory findings revealed significant muscle damage, indicated by an elevated creatine kinase level of 112,114 U/L.

Findings:

  • The patient was diagnosed with exercise-induced rhabdomyolysis.
  • Aggressive hyperhydration led to a rapid decrease in creatine kinase levels.

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  • Renal function remained within normal limits throughout the clinical course.

    • Implications:

    • This case highlights the importance of considering rhabdomyolysis in individuals presenting with relevant symptoms after intense physical activity.
    • Prompt and adequate hydration is an effective strategy for managing exercise-induced rhabdomyolysis and preventing acute kidney injury.
    • Further research into preventative measures and optimal treatment protocols for exertional rhabdomyolysis is warranted.