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Updated: Aug 23, 2025

Study of the Functions and Activities of Neuronal K-Cl Co-Transporter KCC2 Using Western Blotting
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Chloride transporters controlling neuronal excitability

Jessica C Pressey1, Miranda de Saint-Rome1, Vineeth A Raveendran1

  • 1Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.

Physiological Reviews
|October 27, 2022
PubMed
Summary

Cation-chloride cotransporters (CCCs) regulate neuronal chloride gradients, crucial for brain function. Their dysregulation links to neurological disorders, highlighting their therapeutic potential.

Keywords:
KCC2chlorideinhibitionneurophysiologysynaptic transmission

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