Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Network Toxicology and Transcriptomic Analyses Reveal Ferroptosis-Related Neurotoxicity of Rotenone as an Environmental Hazardous Compound.

Cells·2026

Same author

Monitoring brain chemistry: electrochemical techniques and applications.

Bioelectrochemistry (Amsterdam, Netherlands)·2026

Same author

A replenishable peritoneal implant for localized delivery and peritoneal fluid sampling in ovarian cancer.

Device·2026

Same author

Multimodal characterization of sustained bioagent release from an epicardial depot for long-term biomaterial incorporation.

Biomaterials·2026

Same author

Extracellular matrix remodeling therapeutic strategies to tackle central nervous system diseases.

Neural regeneration research·2026

Same author

Low Responsiveness of Macroencapsulated Human Islets Towards Glucose Challenge Despite Excellent Survival in Silicone-Based Oxygen-Delivering Devices.

Bioengineering (Basel, Switzerland)·2026

Same journal

Integration of electrochemical sensors in organ-on-a-chip microfluidic platforms: Advances and perspectives.

Biosensors & bioelectronics·2026

Same journal

DNN-PURE: A deep neural network approach to paper-based urea sensing.

Biosensors & bioelectronics·2026

Same journal

Rationally architected MOF-derived Co<sub>3</sub>O<sub>4</sub>@NiMn-LDH hollow heterostructure-based sensor array empowering sensitive detection and discrimination of neurological biomarkers.

Biosensors & bioelectronics·2026

Same journal

Four-in-one multifunctional CoCu-NC@AuPt nanozyme integrated M13 phage-displayed nanobody based multimodal lateral flow immunoassay for bovine lactoferrin detection.

Biosensors & bioelectronics·2026

Same journal

A novel capillary-driven dual-mode imaging flow cytometry system for malaria parasite detection and quantification.

Biosensors & bioelectronics·2026

Same journal

Liver-targeted alkaline phosphatase-activatable fluorescent probe for imaging liver fibrosis and screening anti-fibrotic natural products.

Biosensors & bioelectronics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Aug 23, 2025

Bridging the Bio-Electronic Interface with Biofabrication

Bridging the Bio-Electronic Interface with Biofabrication

Published on: June 6, 2012

Tethering zwitterionic polymer coatings to mediated glucose biosensor enzyme electrodes can decrease sensor foreign

Kavita Jayakumar¹, Anna Lielpetere², Daniel A Domingo-Lopez³

¹School of Biological & Chemical Sciences, University of Galway, University Road, Galway, H91 TK33, Ireland.

Biosensors & Bioelectronics

|October 27, 2022

Summary

This summary is machine-generated.

Zwitterionic polymer shields reduce foreign body response in implantable glucose biosensors. A poly(2-methacryloyloxyethyl phosphorylcholine-co-glycidyl methacrylate) (MPC) shield enhanced sensor performance and reduced biofouling.

Keywords:

Anti-fouling Coatings Crosslinking Glucose biosensors Lipidure Zwitterionic polymers

More Related Videos

The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions

The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions

Published on: February 1, 2018

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

Related Experiment Videos

Last Updated: Aug 23, 2025

Bridging the Bio-Electronic Interface with Biofabrication

Bridging the Bio-Electronic Interface with Biofabrication

Published on: June 6, 2012

The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions

The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions

Published on: February 1, 2018

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

Area of Science:

Biomaterials Science
Medical Device Engineering
Biomedical Engineering

Background:

Foreign body response (FBR) impedes implantable biosensor longevity, particularly glucose biosensors.
Polymer shields are utilized to mitigate FBR and improve device performance.
Zwitterionic polymers (ZPs) show promise in reducing biofouling on implanted medical devices.

Purpose of the Study:

To synthesize and evaluate novel zwitterionic polymer shields with epoxide functional groups for implantable glucose biosensors.
To assess the ability of these polymer shields to resist protein adsorption and cell adhesion.
To determine the impact of polymer shielding on the performance of amperometric glucose biosensors.

Main Methods:

Synthesis of zwitterionic polymers containing tetherable epoxide functional groups.
Evaluation of polymer shields' resistance to fibrinogen adsorption and fibroblast adhesion.
Coating of amperometric glucose biosensors with polymer shields and assessment of their electrochemical performance (current density, sensitivity).

Main Results:

All synthesized ZPs resisted fibrinogen adsorption similarly to a commercial Lipidure ZP.
A poly(2-methacryloyloxyethyl phosphorylcholine-co-glycidyl methacrylate) (MPC)-type ZP significantly reduced fibrinogen adsorption (approx. 50%) and fibroblast adhesion (approx. 80%) compared to controls.
MPC-coated glucose biosensors exhibited comparable current density and a 1.5-fold increase in sensitivity, outperforming other tested polymer shields.

Conclusions:

MPC-based zwitterionic polymer shields effectively reduce biofouling and foreign body response.
MPC coatings maintain and even enhance the performance of implantable glucose biosensors.
MPC-polymer shields represent a promising strategy for improving the long-term function of implantable glucose sensors and other medical devices.