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Remus: System for remote deep brain interventions.

Taylor D Webb1, Matthew G Wilson1, Henrik Odéen2

  • 1Department of Biomedical Engineering, University of Utah, Salt Lake City, Utah, USA.

Iscience
|October 28, 2022
PubMed
Summary
This summary is machine-generated.

Researchers developed a remote ultrasound system (Remus) for precise, on-demand brain targeting. This noninvasive technology enables personalized treatments for neurological disorders by modulating specific deep brain circuits.

Keywords:
Animal biotechnologyBiodevicesBiological sciencesBiotechnology

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Medical Technology

Background:

  • Transcranial focused ultrasound offers potential for precise neural modulation and targeted drug delivery.
  • Current systems lack the flexibility and on-demand precision required for targeting deep brain circuits.
  • Personalized medicine approaches for brain disorders necessitate advanced, noninvasive targeting technologies.

Purpose of the Study:

  • To develop and validate a novel remote ultrasound system (Remus) for flexible, programmatic targeting of deep brain regions.
  • To demonstrate the system's capability for high spatiotemporal precision and multi-focal modulation.
  • To enable noninvasive diagnosis and treatment of specific deep brain circuits for personalized brain disorder therapies.

Main Methods:

  • Development of a remote ultrasound system (Remus) with programmatic control for deep brain targeting.
  • Validation of the system's precision and multi-focal capabilities in a nonhuman primate model.
  • Modulation of the left and right lateral geniculate nucleus in a task-performing nonhuman primate.

Main Results:

  • The Remus system successfully achieved programmatic targeting of deep brain regions with high spatiotemporal precision.
  • Multi-focal modulation of deep brain nuclei was demonstrated.
  • The system proved effective in modulating specific neural circuits in a nonhuman primate.

Conclusions:

  • The developed Remus system offers a flexible, noninvasive solution for precise deep brain targeting.
  • This technology advances personalized medicine by enabling targeted modulation of neural circuits.
  • Remus holds significant promise for the diagnosis and treatment of various brain disorders.