Related Experiment Video
Updated: Aug 23, 2025
11:32
Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
15.1K
Early-Onset Neonatal Pneumococcal Sepsis: An Old but Sometimes Forgotten Pathogen
Inês Coelho1, Sofia Baptista1, Ana Raquel Ramalho2
1Pediatrics Department, Centro Hospitalar Universitário do Algarve, Faro, PRT.
Cureus
|October 28, 2022
Summary
Streptococcus pneumoniae (SP) can cause serious neonatal sepsis, though uncommon. Prompt treatment is crucial as preventive measures are lacking.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Microbiology
Background:
- Streptococcus pneumoniae (SP) is an uncommon but potentially serious neonatal pathogen.
- While recognized as a cause of infant mortality and morbidity, neonatal sepsis cases are relatively few (1-11% incidence).
Observation:
- Two cases of neonatal SP infection are presented: one with severe early-onset disease (bacteremia, pneumonia, pulmonary hypertension) and another with bacteremia and meningitis.
- SP serotypes 23B and 8 were identified in the respective cases from blood, bronchial secretions, cerebrospinal fluid, and maternal vaginal secretions.
Findings:
- Neonatal SP infections can manifest with diverse clinical presentations, including severe respiratory distress and central nervous system involvement.
- Both neonates were treated successfully with vancomycin and cefotaxime, despite the pathogen's uncommon nature.
Implications:
- Highlights the importance of including SP in the differential diagnosis for early-onset neonatal sepsis.
- Emphasizes the need for prompt and aggressive treatment due to the lack of specific preventive strategies for SP neonatal infections.
- Suggests further research into preventive measures for SP neonatal sepsis is warranted.
More Related Videos
Related Concept Videos
01:29Pneumonia II: Pathophysiology
429
The pathophysiology of pneumonia involves the following steps:
429
01:30Pneumonia I: Introduction
302
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
302
01:30Pneumonia III: Complications and Assessment
363
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
363
01:30Pneumonia V: Nursing management and Prevention
2.4K
Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
2.4K
01:26Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
4.3K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
4.3K
01:28Pneumonia IV: Management
426
The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
426