Related Experiment Video

Updated: Aug 23, 2025

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
05:51

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Published on: July 24, 2016

19.7K

Enteroviral Infections in Infants

Srijan Singh1, Sushant Satish Mane1, Gangajal Kasniya2

  • 1Department of Pediatrics, Grant Government Medical College and Sir JJ Group of Hospitals, Mumbai, Maharashtra, India.

Newborn (Clarksville, Md.)
|October 28, 2022
PubMed

Insights

Enteroviruses (EVs) are significant infant pathogens. This review covers their properties, clinical impacts, and diagnostic, treatment, and prognostic methods, focusing on coxsackie and echoviruses.

Area of Science:

  • Virology
  • Pediatrics
  • Infectious Diseases

Background:

  • Enteroviruses (EVs) are primary pathogens in infants.
  • Traditional classification includes polio, coxsackie A and B, and echoviruses.
  • Coxsackie and echoviruses are gaining attention due to structural similarities and translational medicine potential.

Purpose of the Study:

  • To review enterovirus properties.
  • To detail clinical manifestations and transmission routes.
  • To outline current diagnostic, treatment, and prognostic approaches.

Main Methods:

  • Literature review of enterovirus research.
  • Analysis of clinical presentations and epidemiological data.
  • Summary of laboratory diagnostic techniques (RT-PCR, cell culture, serology).

Main Results:

  • EVs manifest as viral prodromes, meningitis, encephalitis, myopericarditis, and multi-organ failure.
  • Transmission occurs via oral and fecal-oral routes.
  • Diagnosis relies on molecular and serological methods.

Conclusions:

  • Understanding EV properties is crucial for managing infant infections.
  • Current diagnostics and therapeutics offer avenues for prevention and treatment.
  • Further research into coxsackie and echoviruses holds translational medicine promise.

Keywords:
Coxsackie virusEnterovirusesNeonateNewborn

More Related Videos

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates05:53

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Published on: July 6, 2013

15.1K
Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses11:48

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses

Published on: April 4, 2019

16.0K

Related Concept Videos

Viral Recombination00:57

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.7K
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
419
Viral Mutations00:36

Viral Mutations

A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
32.7K
Retroviruses02:33

Retroviruses

Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
12.6K