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Mal De Meleda with Flexural Involvement.
Mitanjali Sethy1, Shibashis Chatterjee1, Chakravarthi R Srinivas1
1Department of Dermatology, Venereology and Leprosy, Kalinga Institute of Medical Sciences (KIMS), KIIT Deemed to be University, Bhubaneswar, Odisha, India.
Indian Dermatology Online Journal
|October 28, 2022
Summary
Mal de Meleda, a rare palmoplantar keratoderma, typically affects hands and feet. This study details a unique case with unusual flexural skin involvement, expanding the known clinical presentation of this genetic disorder.
Area of Science:
- Dermatology
- Medical Genetics
- Rare Diseases
Background:
- Mal de Meleda is a rare autosomal recessive palmoplantar keratoderma with a prevalence of approximately 1 in 100,000.
- The condition typically manifests in infancy with progressive keratoderma on palms and soles, extending to the dorsum of hands and feet.
- Extensor surfaces of knees and elbows are commonly affected.
Observation:
- This report describes a rare case of Mal de Meleda presenting with flexural skin involvement.
- Flexural involvement has not been previously documented in the medical literature for Mal de Meleda.
Findings:
- The case highlights an atypical clinical manifestation of Mal de Meleda.
- This expands the spectrum of skin conditions associated with palmoplantar keratoderma.
Implications:
- This finding may necessitate a re-evaluation of diagnostic criteria and clinical assessment for Mal de Meleda.
- Further research into the genetic and molecular basis of this variant presentation is warranted.
- Clinicians should consider flexural involvement in the differential diagnosis of palmoplantar keratoderma.
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