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Related Concept Videos

Flexural Stress01:16

Flexural Stress

344
When analyzing bending in symmetric members, it's crucial to understand how stresses distribute when subjected to bending moments. This stress distribution is effectively described by applying fundamental mechanics and material science principles, particularly Hooke's Law for elastic materials.
Hooke's Law states that within the material's elastic limits, stress is directly proportional to strain. In a member experiencing a bending moment, the strain at any point is relative to...
344
Vascular Spasm01:16

Vascular Spasm

1.6K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
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Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

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IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
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Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

31
IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
31
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

16
Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
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Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

26
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
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Updated: Aug 23, 2025

C-arm-Free Simultaneous OLIF51 and Percutaneous Pedicle Screw Fixation in a Single Lateral Position
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Mal De Meleda with Flexural Involvement.

Mitanjali Sethy1, Shibashis Chatterjee1, Chakravarthi R Srinivas1

  • 1Department of Dermatology, Venereology and Leprosy, Kalinga Institute of Medical Sciences (KIMS), KIIT Deemed to be University, Bhubaneswar, Odisha, India.

Indian Dermatology Online Journal
|October 28, 2022
PubMed
Summary
This summary is machine-generated.

Mal de Meleda, a rare palmoplantar keratoderma, typically affects hands and feet. This study details a unique case with unusual flexural skin involvement, expanding the known clinical presentation of this genetic disorder.

Keywords:
DermatoglyphicsMDMMal de MeledaPPKpalmoplantar keratoderma

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Area of Science:

  • Dermatology
  • Medical Genetics
  • Rare Diseases

Background:

  • Mal de Meleda is a rare autosomal recessive palmoplantar keratoderma with a prevalence of approximately 1 in 100,000.
  • The condition typically manifests in infancy with progressive keratoderma on palms and soles, extending to the dorsum of hands and feet.
  • Extensor surfaces of knees and elbows are commonly affected.

Observation:

  • This report describes a rare case of Mal de Meleda presenting with flexural skin involvement.
  • Flexural involvement has not been previously documented in the medical literature for Mal de Meleda.

Findings:

  • The case highlights an atypical clinical manifestation of Mal de Meleda.
  • This expands the spectrum of skin conditions associated with palmoplantar keratoderma.

Implications:

  • This finding may necessitate a re-evaluation of diagnostic criteria and clinical assessment for Mal de Meleda.
  • Further research into the genetic and molecular basis of this variant presentation is warranted.
  • Clinicians should consider flexural involvement in the differential diagnosis of palmoplantar keratoderma.