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Published on: October 6, 2023
VENOMOUS SNAKEBITES IN CROATIA, CLINICAL PRESENTATION, DIAGNOSIS AND TREATMENT
Darinka Tunjić Pejak1, Višnja Nesek Adam1,2,3, Ivana Srzić1
1Clinical Hospital Sveti Duh, Department of Emergency Medicine, Zagreb.
Insights
Venomous snake bites are a significant global health issue. In Croatia, while venomous snakes exist, severe outcomes from ophidism (snake venom envenomation) are rare due to prompt medical care.
Area of Science:
- Toxicology
- Public Health
- Herpetology
Background:
- Venomous snake bites pose a major global health threat, particularly in tropical and subtropical regions.
- Over 3 million snake bites and 100,000 deaths occur annually worldwide.
- Croatia experiences venomous snake bites, but with a low mortality rate.
Purpose of the Study:
- To highlight the public health impact of venomous snake bites.
- To describe the venomous snake species in Croatia.
- To outline the clinical presentation and management of ophidism.
Main Methods:
- Review of global and national snake bite statistics.
- Identification of venomous snake species in Croatia: Vipera ammodytes, Vipera berus, and Vipera ursinii macrops.
- Description of the pathophysiology and diagnostic challenges of ophidism.
Main Results:
- Croatia reported 632 hospitalizations for snake bites with only 3 deaths.
- The clinical effects of snake venom include hematotoxic, neurotoxic, myotoxic, and cytotoxic impacts.
- Diagnosis of systemic envenomation relies on clinical signs and tests, as no specific test for venom spread exists.
Conclusions:
- Ophidism requires urgent medical attention following initial first aid.
- Timely transport to a medical facility is crucial for assessing severity and initiating treatment.
- Understanding snake venom's effects and diagnostic limitations is key to managing ophidism.
Abstract:
Venomous snake bites are recognized as a major public health problem, affecting mostly poor, underdeveloped areas in the tropical and subtropical areas. Every year, more than three million bite cases and about 100,000 deaths are registered worldwide. Over the past years, 632 people have been hospitalized in Croatia with only 3 deaths due to venomous snake bites. Favorable geographic position, warm climate and great biodiversity of Croatia have resulted in the development of a total of 15 species of snakes, of which only 3 are venomous: horned viper (Vipera ammodytes), the common European viper (Vipera berus) and meadow viper (Vipera ursinii macrops). Snake venom envenomation is called ophidism (greek ofis=snake). Snake venoms are complex mixtures of proteins and toxins that have a wide range of toxic effects. The clinical presentation of ophidism is due to hematotoxic, neurotoxic, myotoxic (cardiotoxic) and cytotoxic effects of venom. There is currently no test to identify patients with a systemic spread of the venom, the diagnosis is made by a combination of diagnostic tests, clinical symptoms and sings of systemic envenomation. Ophidism is a medical condition that requires urgent treatment. Following first aid given at the scene, the patient should be transported to the closest medical facility to assess the severity of the clinical presentation in a timely manner and take the necessary treatment measures.
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