Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...

Drug Delivery: Miscellaneous Routes

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...

Drug Delivery: Parenteral Route

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...

Factors Affecting Drug Response: Overview

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...

Drug Delivery: Enteral Route

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correction: Follicular dendritic cell sarcoma associated with IgG4-related disease: a case report and literature review.

Frontiers in immunology·2026

Same author

Ultrarapid Kinetic Antimicrobial Susceptibility Testing from Blood Using Single-Cell Scattering Phenotypic Imaging.

ACS sensors·2026

Same author

A Single-Sided Knot Modification of Diameter-Reducing Ties for Physician-Modified Endografts.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2026

Same author

Integrative Multi-Omics Analysis Reveals the Tumor-Suppressive and Immunoregulatory Roles of SEMA5B in Prostate Cancer.

BioFactors (Oxford, England)·2026

Same author

Follicular dendritic cell sarcoma associated with IgG4-related disease: a case report and literature review.

Frontiers in immunology·2026

Same author

ClWRKY75 regulates lignin biosynthesis to confer Colletotrichum fructicola resistance in watermelon.

Plant physiology and biochemistry : PPB·2026

Search research articles

Related Experiment Video

Updated: Aug 23, 2025

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa

Published on: September 27, 2018

Electronically powered drug delivery devices: considerations and challenges.

Guang Liu¹, Yanli Lu¹, Fenni Zhang¹

¹Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, P. R. China.

Expert Opinion on Drug Delivery

|October 28, 2022

Summary

This summary is machine-generated.

Electronically powered drug delivery systems offer controlled, convenient, and painless medication administration. Advances in microelectronics enable smart, miniaturized devices for on-demand drug delivery, improving patient outcomes.

Keywords:

Drug delivery device closed-loop drug delivery electronic capsule electronic micropump electronic patch electronically powered device microchip

More Related Videos

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Published on: August 18, 2023

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 17, 2013

Related Experiment Videos

Last Updated: Aug 23, 2025

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa

Published on: September 27, 2018

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Published on: August 18, 2023

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 17, 2013

Area of Science:

Biomedical Engineering
Drug Delivery Systems
Microfabrication

Background:

Electronically powered drug delivery devices offer controlled release, enhancing convenience and reducing side effects.
Miniaturization and intelligence are achieved through microfabrication and microelectronics integration.
These smart devices are crucial for commercialized on-demand drug delivery.

Approach:

This review provides an overview of electronically powered drug devices.
Focuses on delivery strategies, manufacturing techniques, and control circuit design.
Includes specific examples of current progress.

Key Points:

Electronically powered drug delivery systems are a feasible therapeutic approach.
Improved drug release efficiency and increased patient comfort are key benefits.
Integration of sensors and wireless communication enhances device intelligence.

Conclusions:

Future applications in clinical therapy are anticipated.
These technologies aim to meet clinical needs and overcome commercialization challenges.
Focus on effective drug release strategies and future perspectives.