Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

3.4K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
3.4K
Functional Brain Systems: Reticular Formation01:13

Functional Brain Systems: Reticular Formation

2.4K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
2.4K
Association Areas of the Cortex01:21

Association Areas of the Cortex

5.9K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
5.9K
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

556
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
556
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

626
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
626

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clarifications and response to "Validating plasma biomarkers for distinguishing neurodegenerative and psychiatric disorders" by Boccardi et al.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Von Economo Neuron Loss in Frontotemporal Dementia: A Meta-Analysis of Neuropathological Studies.

Annals of clinical and translational neurology·2026
Same author

Risk and protective factors associated with brain grey matter patterns in a population-based cohort of cognitively unimpaired 70 years old.

BMC medicine·2025
Same author

Clinical recognition of frontotemporal dementia with right temporal predominance: a consensus statement from the International Working Group.

Communications medicine·2025
Same author

Plasma p-tau217, NfL, GFAP diagnostic performance and biomarker profiles in Alzheimer's disease, frontotemporal dementia, and psychiatric disorders, in a prospective unselected neuropsychiatry memory clinic.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Risk and protective factors associated with brain grey matter patterns in a population-based cohort of cognitively unimpaired 70-year-olds.

Research square·2025
Same journal

Voices of Stroke Survivors With Dysphagia: A Roy Adaptation Model-Based Qualitative Analysis.

Brain and behavior·2026
Same journal

Korean Red Ginseng Attenuates Dysfunctions and Modulates Inflammatory and Neuroplasticity Markers in the Harmaline-Induced Model of Essential Tremor.

Brain and behavior·2026
Same journal

Pseudohallucination and Pilocytic Astrocytoma in the Pons.

Brain and behavior·2026
Same journal

Volume Alterations in Thalamic Subnuclei in Parkinson's Disease Dementia and Machine Learning-Based Prediction of Diagnosis and Severity.

Brain and behavior·2026
Same journal

ESTELA-Study: Long-Term Effectiveness and Safety of Anti-Calcitonin Gene-Related Peptide Monoclonal Antibodies in Real-World Clinical Practice.

Brain and behavior·2026
Same journal

The "Brain's Traffic Map" Reveals Neural Pathways Linked to Coronary Microvascular Dysfunction in Women.

Brain and behavior·2026
See all related articles

Related Experiment Video

Updated: Aug 23, 2025

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

25.3K

Functional connectivity in behavioral variant frontotemporal dementia.

Luiz Kobuti Ferreira1,2, Olof Lindberg1, Alexander F Santillo3

  • 1Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.

Brain and Behavior
|October 28, 2022
PubMed
Summary
This summary is machine-generated.

Functional connectivity (FC) in behavioral variant frontotemporal dementia (bvFTD) shows decreased salience network connectivity and reduced overall brain efficiency. These changes correlate with symptoms and resemble neuropathological spread patterns.

Keywords:
brainbvFTDfMRIfrontotemporal dementiafunctional connectivity

More Related Videos

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

7.3K
A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

10.3K

Related Experiment Videos

Last Updated: Aug 23, 2025

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

25.3K
Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

7.3K
A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

10.3K

Area of Science:

  • Neuroscience
  • Neurology
  • Neuroimaging

Background:

  • Functional connectivity (FC) assesses neural activity relationships, crucial for understanding brain function in neurodegenerative diseases.
  • Behavioral variant frontotemporal dementia (bvFTD) is increasingly studied using FC, yet a focused review is lacking.

Purpose of the Study:

  • To provide an in-depth review of functional connectivity alterations in behavioral variant frontotemporal dementia (bvFTD).
  • To synthesize current findings on FC in bvFTD for a comprehensive understanding.

Main Methods:

  • A comprehensive literature search was conducted.
  • A narrative review approach was employed to summarize existing research on FC in bvFTD.

Main Results:

  • Consistent finding of decreased FC within the salience network (SN) in bvFTD.
  • FC alterations extend beyond the SN, impacting inter-network communication.
  • Reduced overall brain network interconnectedness and efficiency observed in bvFTD.
  • Association between FC changes, clinical symptoms, functional impairment, and cognitive status.
  • Observed FC patterns mirror neuropathological spread in bvFTD.

Conclusions:

  • Functional connectivity shows promise as a biomarker for bvFTD.
  • Future research directions include multicentric studies, longitudinal designs, and methodological advancements to refine understanding of FC in bvFTD.