COVID-19 vaccinations in pregnancy: Save mother and baby from COVID-19 pandemic

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Updated: Aug 23, 2025

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C
07:13

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Published on: March 25, 2016

18.6K

Amala Sunder1, Huda Merza Alqatari2, Omer E Taha2

  • 1Bahrain Defense Force Hospital, Riffa, Bahrain.

International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics
|October 28, 2022
PubMed

Insights

Maternal COVID-19 vaccination with Sinopharm or Pfizer/BioNTech generated significant antibodies, with 100% showing vertical transmission to neonates. Antibody levels varied between vaccines and correlated with maternal and fetal factors.

Area of Science:

  • Immunology
  • Vaccinology
  • Perinatology

Background:

  • Maternal vaccination against coronavirus disease 2019 (COVID-19) is crucial for protecting pregnant individuals and neonates.
  • Understanding the immune response and antibody transfer following different COVID-19 vaccines in pregnancy is essential.

Purpose of the Study:

  • To investigate the immune response in pregnant women vaccinated with Sinopharm or Pfizer/BioNTech.
  • To assess the vertical transmission of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) and nucleocapsid (N) proteins from mother to neonate.

Main Methods:

  • Retrospective study of 79 pregnant women vaccinated with Sinopharm or Pfizer/BioNTech.
  • Analysis of anti-N and anti-S antibody levels in paired maternal and umbilical cord blood samples.
  • Correlation of antibody titers and transfer ratios with maternal and fetal factors.

Main Results:

  • All vaccinated pregnant women (100%) generated anti-N and anti-S antibodies.
  • Vertical transmission of antibodies to neonates was observed in all cases.
  • Antibody titers and transfer ratios varied between Sinopharm and Pfizer/BioNTech vaccines.
  • Antibody transfer correlated differently with maternal age, gestational age, latency, and birth weight for each vaccine.

Conclusions:

  • Both Sinopharm and Pfizer/BioNTech vaccines induce significant antibody production in pregnant women.
  • Vertical transmission of protective antibodies to neonates occurs effectively with both vaccine types.
  • Variations in antibody response and transfer exist between different COVID-19 vaccines used during pregnancy.
Abstract

Keywords:
anti-SARS-CoV-2gestational agelatency periodmaternal agepaired samplespike and nucleocapsid proteinstransfer ratioumbilical cordvaccination

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