Drimane-type sesquiterpenoids from fungi

Area of Science:

• Natural Product Chemistry
• Organic Chemistry
• Mycology

Background:

• Sesquiterpenoids are C15 terpenoids derived from farnesyl diphosphate.
• Drimane-type sesquiterpenoids possess a unique decahydronaphthalene core structure.
• These compounds exhibit diverse biological activities and have been extensively studied.

Purpose of the Study:

• To review new drimane-type sesquiterpenoids isolated from fungi.
• To classify these compounds based on structural features.
• To highlight their chemical diversity, bioactivities, and biosynthetic origins.

Main Methods:

• Literature search for drimane-type sesquiterpenoids from fungal sources.
• Data collection from January 2004 to October 2021.
• Classification of compounds into major subfamilies.

Main Results:

• 164 new drimane-type sesquiterpenoids were identified.
• Compounds were categorized into three primary subfamilies.
• Diverse chemical structures and reported bioactivities were summarized.

Conclusions:

• Drimane-type sesquiterpenoids represent a significant class of fungal natural products.
• Further research can elucidate more complex biosynthetic pathways.
• This review provides a comprehensive overview for future investigations.