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Immunohistochemical evaluation of E-cadherin in oral epithelial dysplasia and squamous cell carcinoma
Jaishree Sharma1, Manish Bhargava1, Shivani Aggarwal1
1Department of Oral Pathology and Microbiology, Manav Rachna Dental College, Faridabad, Haryana, India.
Aim:
To evaluate the expression of E-cadherin (E-cad) in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC).
Material And Method:
Immunohistochemistry was used to detect E-cad expression in 20 cases each of normal oral mucosa, oral epithelial dysplasia and squamous cell carcinoma.
Statistical Analysis Used:
Inferential statistical methods for statistical analysis used were Chi-square test for comparison of the frequency between different severity of dysplasia and OSCC.
Results:
Upon assessing the expression of E-cad in OED and OSCC, increase in E-cad immunoreactivity was seen in early lesions. However, the expression of E-cad decreased significantly as the grade of dysplasia increased.
Conclusion:
We observed a significant decrease in E-cad expression from dysplasia to poorly differentiated squamous cell carcinoma suggesting that loss of expression of E-cad is closely related to carcinoma.
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