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Tumor budding is a valuable prognostic parameter in endometrial carcinomas
1Department of Pathology, Ataturk Training and Research Hospital, Izmir Katip Celebi University, Izmir, Turkey.
Indian Journal of Pathology & Microbiology
|October 29, 2022
Summary
Tumor budding (TB) is a significant indicator of poor prognosis in endometrial cancer. This study found that the presence of TB negatively impacts overall survival, even in early-stage disease, highlighting its value as a prognostic marker.
Area of Science:
- Gynecologic Oncology
- Pathology
- Cancer Research
Background:
- Tumor budding (TB) is a recognized morphological feature associated with prognosis in various cancers.
- Its specific role in endometrial carcinoma requires further elucidation.
Purpose of the Study:
- To investigate the prognostic significance of tumor budding in endometrial carcinomas.
- To determine if TB impacts overall survival in endometrial cancer patients.
Main Methods:
- A cohort of 211 endometrial cancer cases diagnosed between 2008-2015 with at least 5 years of follow-up were analyzed.
- Hematoxylin and eosin stained slides were re-evaluated for the presence and status of tumor budding.
- Statistical analyses included nonparametric tests, Kaplan-Meier, Log-rank test, and Cox regression.
Main Results:
- Tumor budding correlated significantly with larger tumor diameter, non-endometrioid histology, mixed cell types, higher tumor grade, deeper myometrial invasion, cervical stromal invasion, advanced pT stage, lymph node involvement, lymphovascular invasion, and advanced overall stage.
- The presence of TB was associated with a significantly worse 5-year overall survival (OS).
- Even in early-stage (grade 1, pT1, stage 1) endometrial carcinomas, TB presence decreased OS rates.
Conclusions:
- Tumor budding is an adverse prognostic factor in endometrial carcinoma.
- TB status adversely affects patient prognosis and overall survival.
- Tumor budding should be considered a valuable prognostic parameter in endometrial cancer management.
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