Related Experiment Video
Updated: Aug 23, 2025
03:05
Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors
Published on: February 16, 2024
1.1K
Giant hyperplastic gastric polyp: A diagnostic dilemma!!
Ashish Jain1, Dimple Chaudhary1, Surbhi Goyal1
1Department of Pathology and Gastrointestinal Surgery, GIPMER, New Delhi, India.
Indian Journal of Pathology & Microbiology
|October 29, 2022
Summary
Giant gastric hyperplastic polyps (GHPs) can mimic stomach cancer. This case highlights the importance of histopathology in diagnosing these rare, large polyps that cause gastric outlet obstruction.
Area of Science:
- Gastroenterology
- Surgical Pathology
Background:
- Gastric hyperplastic polyps (GHPs) are common benign gastric lesions.
- Most GHPs are small (<2 cm), asymptomatic, and incidentally found.
- Larger GHPs can cause symptoms like bleeding, anemia, and gastric outlet obstruction (GOO).
Observation:
- A 46-year-old female presented with a year of progressive GOO.
- Endoscopy revealed an eccentric proliferative antral lesion.
- CT showed a large (8.4 cm) polypoidal mural thickening in the distal stomach.
Findings:
- Subtotal gastrectomy was performed due to suspected malignancy and GOO.
- Gross examination revealed a giant sessile hyperplastic polyp.
- Microscopy confirmed a large GHP without dysplasia.
Implications:
- Giant GHPs can radiologically and endoscopically resemble gastric carcinoma.
- Consider giant GHP in cases of intensely enhancing, large gastric polyps.
- Long-term endoscopic surveillance is recommended for giant GHPs.
More Related Videos
Related Concept Videos
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
179
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
179
01:23Gastritis III: Clinical Manifestations and Management
399
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
399
01:16Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
515
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
515
01:21Barrett Esophagus-II: Clinical Manifestations and Management
264
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
264
01:30Peptic Ulcer Disease I: Introduction
261
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
261
01:29Endoscopic Procedures I: Esophagogastroduodenoscopy
332
An Esophagogastroduodenoscopy (EGD) is a diagnostic procedure in which an endoscopist uses a flexible, lighted endoscope to visualize the upper gastrointestinal (GI) tract. The procedure includes visualizing the oropharynx, esophagus, stomach, and the first part of the small intestine, the duodenum.
During an EGD, the endoscope can be used to:
During an EGD, the endoscope can be used to:
332