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Primary hepatic lymphoma- A diagnostic dilemma
Purushotham Reddy1, Sunita S Vernekar1, P Sneha1
1Department of Pathology, Karnataka Institute of Medical Sciences, Hubli, Karnataka, India.
Indian Journal of Pathology & Microbiology
|October 29, 2022
Summary
This case report details a rare instance of primary non-Hodgkin lymphoma of the liver in a 50-year-old female. Diagnosis was confirmed as Burkitt
Area of Science:
- Hepatobiliary Malignancies
- Hematologic Oncology
- Diagnostic Pathology
Background:
- Primary non-Hodgkin lymphoma (NHL) of the liver is an exceptionally rare clinical entity.
- Early diagnosis is often challenging due to non-specific symptoms and rarity.
Observation:
- A 50-year-old female presented with right upper quadrant pain and appetite loss.
- Imaging revealed a large liver lesion; staging scans excluded systemic involvement.
- Standard tumor markers and viral serologies were unremarkable.
Findings:
- Pathological examination strongly suggested Burkitt's lymphoma.
- A high Ki-67 proliferation index (>70%) was noted.
- MYC translocation t(8;14) was recommended for definitive diagnosis.
Implications:
- Highlights the importance of considering primary hepatic lymphoma in liver masses.
- Emphasizes the role of advanced diagnostics, including cytogenetics, for rare hematologic malignancies.
- Contributes to understanding the clinical presentation and diagnostic pathway for primary liver Burkitt's lymphoma.
