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Updated: Aug 23, 2025
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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
Published on: March 11, 2021
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Method for spot urine normalization by 40K in a radiation emergency.
Jaeryong Yoo1, MinSeok Park1, Hansung Kim1
1Laboratory of Health Physics, National Radiation Emergency Medical Center, Korea Institute of Radiological & Medical Sciences, Seoul, Republic of Korea.
Summary
Assessing internal radiation dose in emergencies, this study found that 40K (Potassium-40) activity concentration in urine can complement creatinine normalization. This aids in accurate dose assessment during radiological events.
Area of Science:
- Nuclear Science
- Radiological Health
- Biomedical Analysis
Background:
- Accurate internal radiation dose assessment is critical during radiation emergencies.
- Spot urine analysis is a common method for monitoring internal contamination.
- Established normalization methods, like creatinine, have limitations.
Purpose of the Study:
- To evaluate the variability of spot urine normalization techniques for internal radiation dose assessment.
- To investigate the utility of 40K (Potassium-40) activity concentration as a complementary normalization method.
Main Methods:
- Analysis of spot urine samples to measure creatinine concentration.
- Measurement of 40K (Potassium-40) activity concentration in the same urine samples.
- Comparison of 40K normalization with creatinine normalization methods.
Main Results:
- The mean creatinine concentration in spot urine samples was 139 mg dL⁻¹.
- The mean 40K activity concentration was 106 Bq kg⁻¹.
- Results suggest 40K activity concentration is a viable complementary normalization method.
Conclusions:
- The 40K activity concentration method offers a valuable addition to creatinine normalization for spot urine analysis.
- This combined approach can enhance the accuracy of internal radiation dose assessments in radiological emergencies.
- Further validation of 40K normalization in diverse emergency scenarios is warranted.
