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Method for spot urine normalization by 40K in a radiation emergency

Jaeryong Yoo1, MinSeok Park1, Hansung Kim1

  • 1Laboratory of Health Physics, National Radiation Emergency Medical Center, Korea Institute of Radiological & Medical Sciences, Seoul, Republic of Korea.

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
|October 29, 2022
PubMed

Keywords:
(40)K activity ConcentrationInternal dosimetryNormalizationRadiation emergencySpot urine

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The one-compartment open model leverages urinary excretion data to estimate renal clearance, which gauges the kidney's capacity to expel a drug. This method offers several benefits, including directly measuring drug elimination and assessing the kidney's contribution to overall drug clearance. However, this approach has limitations. It assumes sole renal excretion of the drug, which is not true for all drugs. Accurate urinary excretion and plasma drug concentration measurement can also...
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