Phenolic C-glycoside synthesis using microbial systems

Plants produce different types of phenolic compounds. The majority of these compounds are glycosylated. Phenolic O-glycosides are also common. Recently, C-glycosylation of phenolic compounds has received attention because of the biological importance of phenolic C-glycosides. To date, three classes of C-glycosyltransferases (CGTs) have been characterized based on the type of sugar acceptor: flavonoid CGT, coumarin CGT, and xanthone CGT. Phylogenetic analysis of glycosyltransferases has revealed that CGTs form a distinct class that is clearly different from that of O-glycosyltransferases. The characterized CGTs have been introduced into microbial systems to synthesize phenolic C-glycosides. Here, we review recent progress in the development of CGTs and their application in the synthesis of phenolic C-glycosides using microbial systems.