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Updated: Aug 23, 2025

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
Published on: January 22, 2016
Neurological Manifestations of Chronic Methadone Maintenance Therapy: A Case Report and Literature Review
Ulviyya Gasimova1, Khurram M Afzal1, Aninda B Acharya1
1Neurology, Saint Louis University School of Medicine, St. Louis, USA.
Abstract:
Methadone is a long-acting opioid medication that is used as maintenance therapy for heroin addiction. We present a case of a patient on methadone maintenance therapy for chronic back pain who developed neurological complications. The patient presented with mental status changes and choreiform movements. Workup revealed lesions involving the subcortical white matter and basal ganglia. Choreiform movements improved after the initiation of treatment with topiramate, clonazepam, and risperidone. This combination was chosen as several prior case reports published significant benefit and improvement in choreiform movements with the mentioned regimen.
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