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Internal Bleeding Extending to the Retroperitoneum and Right Psoas With Severe Acute Respiratory Syndrome Coronavirus
Sarah Hatahet1, Magdi S Yacoub2, Mina Farag3
1Internal Medicine, University of Novi Sad, Novi Sad, SRB.
Insights
Severe COVID-19 patients on anticoagulation face bleeding risks. A Jehovah's Witness experienced a near-fatal bleed, highlighting the need for careful risk assessment and transfusion alternatives.
Area of Science:
- Critical Care Medicine
- Hematology
- Infectious Diseases
Background:
- Coronavirus disease 2019 (COVID-19) is linked to coagulopathy and thromboembolic events.
- Anticoagulant use has increased significantly in managing COVID-19 patients.
- Bleeding complications are a known adverse effect of anticoagulation therapy.
Observation:
- A 60-year-old male with severe COVID-19 requiring ICU admission and mechanical ventilation developed a retroperitoneal hemorrhage.
- The patient, a Jehovah's Witness, refused blood transfusions, complicating management.
- The bleed resulted in a 50% drop in hemoglobin levels.
Findings:
- Anticoagulation in critically ill COVID-19 patients carries a substantial risk of potentially fatal bleeding events.
- Management protocols for anticoagulation in SARS-CoV-2 infection vary.
- Individualized risk-benefit analysis of anticoagulation is crucial.
Implications:
- Early detection and intervention for bleeding are vital in COVID-19 patients on anticoagulation.
- Clinicians must consider alternatives to blood transfusion when managing hemorrhage in patients who refuse transfusions.
- Balancing the risks of thrombosis and bleeding is essential for optimal patient outcomes.
Abstract:
Coronavirus disease 2019 (COVID-19 - severe acute respiratory syndrome coronavirus 2 {SARS-CoV-2}) infection has been associated with thromboembolic events and coagulopathy, leading to a surge in the use of anticoagulants. The dose and duration of therapy differ according to the followed protocol. Several case reports documented fatal bleeding as an adverse effect of anticoagulation. We report a case of nearly fatal retroperitoneal bleed in an otherwise healthy 60-year-old man who developed severe COVID-19 requiring ICU stay and mechanical ventilation. The development of retroperitoneal bleed led to a 50% drop in his hemoglobin. The patient happens to be a Jehovah's Witness, and the family refused blood transfusion, which added to the complexity of the situation. Anticoagulation is associated with a potential risk of fatal bleed in critically ill COVID-19 patients. There are different protocols of anticoagulation in the management of SARS-CoV-2. The risk of bleeding vs thrombosis should be weighed on a case-by-case basis. A high degree of suspicion, early intervention, and knowledge of alternatives to blood transfusion can improve outcomes.
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