Metabolic syndrome as a common comorbidity in adults with hypothalamic dysfunction
Zhuoran Xu1,2, Xiaoan Ke1,2, Xianxian Yuan1,2,3
1Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases, The Translational Medicine Center of Peking Union Medical College Hospital (PUMCH), PUMCH, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing, China.
Frontiers in Endocrinology
|October 31, 2022
Summary
Hypothalamic dysfunction (HD) is linked to metabolic syndrome, especially in adults with pituitary hormone deficiencies or obesity. HD significantly increases the risk of metabolic syndrome, even after adjusting for BMI.
Area of Science:
- Endocrinology
- Metabolic Health
- Clinical Research
Background:
- Hypothalamic dysfunction (HD) is associated with endocrine disorders and metabolic comorbidities.
- Understanding the clinical and metabolic profiles of adults with HD is crucial for patient management.
Purpose of the Study:
- To analyze the clinical characteristics and metabolic abnormalities in adults with hypothalamic dysfunction.
- To identify risk factors for metabolic syndrome in patients with HD.
Main Methods:
- Retrospective review of adult patients with HD from August 1989 to October 2020.
- Comparison of metabolic characteristics with age-, sex-, and BMI-matched controls.
Main Results:
- Temperature dysregulation (61.0%) and hypogonadotropic hypogonadism were common.
- Metabolic syndrome (MetS) was prevalent in 52.5% of patients with HD, significantly higher than controls.
- HD was a significant risk factor for MetS (OR 2.919) after adjusting for age, sex, and BMI.
Conclusions:
- Temperature dysregulation and hypogonadotropic hypogonadism are key dysfunctions in HD.
- Metabolic syndrome and unfavorable metabolic profiles are common in adults with HD.
- Hypothalamic dysfunction is an independent risk factor for metabolic syndrome.
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