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Correlation between urinary and serum NT-proBNP in acute bronchiolitis: A pilot study.
Moises Rodríguez-González1,2, Ana Castellano-Martínez2,3, Ana Estalella-Mendoza2,4
1Pediatric Cardiology Division, Puerta del Mar University Hospital, Cádiz, Spain.
Urinary N-terminal pro-brain natriuretic peptide (NT-proBNP) strongly correlates with serum levels and can indicate severity in acute bronchiolitis. This noninvasive marker shows potential for assessing complicated cases and guiding treatment decisions.
Area of Science:
- Pediatric critical care medicine
- Biomarker research
- Respiratory infections
Background:
- Acute bronchiolitis is a common respiratory infection in infants.
- Assessing severity and predicting outcomes can be challenging.
- N-terminal pro-brain natriuretic peptide (NT-proBNP) is a known cardiac biomarker.
Purpose of the Study:
- To investigate the correlation between urinary and serum NT-proBNP concentrations.
- To evaluate the association of urinary NT-proBNP with the severity of acute bronchiolitis.
- To explore the potential of urinary NT-proBNP as a noninvasive severity marker.
Main Methods:
- Pilot observational study including 17 infants with acute bronchiolitis.
- Time-matched serum and urine samples were analyzed for NT-proBNP.
- Statistical analyses included Spearman's correlations and linear regression.
Main Results:
- Urinary NT-proBNP strongly correlated with serum NT-proBNP (ρ = 0.81).
- Elevated urinary NT-proBNP was associated with higher C-reactive protein, procalcitonin, and pCO2.
- Higher urinary NT-proBNP levels correlated with need for ventilatory support and longer hospitalization.
Conclusions:
- Urinary NT-proBNP is a reliable surrogate for serum NT-proBNP.
- Urinary NT-proBNP levels are elevated in severe acute bronchiolitis.
- Urinary NT-proBNP shows promise as a noninvasive tool for assessing bronchiolitis severity.
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