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Updated: Aug 23, 2025
Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery
Published on: April 17, 2012
Hierarchically mesoporous Ce-based MOFs with enhanced alkaline phosphatase-like activity for phosphorylated biomarker
Rui Gao1, Niru Ye1, Xiaoxue Kou1
1MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University, Guang-zhou 510275, China. chengsh39@mail.sysu.edu.cn.
Abstract:
Herein, we develop a hierarchically mesoporous cerium metal-organic framework (Ce-HMMOF) nanozyme with enhanced ALP-mimicking activity for the naked-eye detection of phosphorylated biomarkers. The long-range ordered mesochannels (9.18 nm) throughout the Ce-HMMOF promote both the mass transfer and the accessibility of interior active sites, permitting the rapid and sensitive sensing of phosphorylated biomarkers through ALP-like biocatalysis. This work provides a new insight into the engineering of highly active nanozymes for disease-associated biomarker screening and diagnosis.
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